1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Glipizide

Glipizide (Synonyms: CP 28720; K 4024)

Cat. No.: HY-B0254 Purity: 99.57%
Handling Instructions

Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans.

For research use only. We do not sell to patients.

Glipizide Chemical Structure

Glipizide Chemical Structure

CAS No. : 29094-61-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 92 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Description

Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].

IC50 & Target

IC50: 6.4 nM ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells[1]

In Vitro

Glipizide inhibits ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells (IC50= 6.4 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

445.54

Formula

C21H27N5O4S

CAS No.
SMILES

O=C(C1=NC=C(C)N=C1)NCCC2=CC=C(S(=O)(NC(NC3CCCCC3)=O)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (112.22 mM; Need ultrasonic)

H2O : 0.67 mg/mL (1.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2445 mL 11.2223 mL 22.4447 mL
5 mM 0.4489 mL 2.2445 mL 4.4889 mL
10 mM 0.2244 mL 1.1222 mL 2.2445 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.61 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.61 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Glipizide
Cat. No.:
HY-B0254
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