2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Neuromedin B

Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

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Neuromedin B

Neuromedin B Estructura química

No. CAS : 87096-84-2

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Based on 1 publication(s) in Google Scholar

Neuromedin B Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Neuromedin B

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Human Endogenous Metabolite Microbial Metabolite

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Descripciòn

Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
CHO EC50
120 nM
Compound: 2 (NMB)
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
[PMID: 12723954]
CHO EC50
41 nM
Compound: 2 (NMB)
Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assay
Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assay
[PMID: 12723954]
CHO EC50
4500 nM
Compound: 2 (NMB)
Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.
Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.
[PMID: 12723954]
In Vitro

Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuromedin B Related Antibodies
In Vivo

Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

1132.29

Fòrmula

C52H73N15O12S
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Sequence Shortening

GNLWATGHFM-NH2
Structure Classification
Initial Source

mammals
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 2 mg/mL (1.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8832 mL 4.4158 mL 8.8317 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8832 mL 4.4158 mL 8.8317 mL 22.0791 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Neuromedin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuromedin B87096-84-2Endogenous MetaboliteInhibitorinhibitorinhibit

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Nombre del producto:
Neuromedin B
Cat. No.:
HY-P0241
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