1. Anti-infection
  2. Bacterial
  3. Octenidine dihydrochloride

Octenidine dihydrochloride 

Cat. No.: HY-B2170A Purity: >98.0%
Handling Instructions

Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.

For research use only. We do not sell to patients.

Octenidine dihydrochloride Chemical Structure

Octenidine dihydrochloride Chemical Structure

CAS No. : 70775-75-6

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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5 g USD 108 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.

In Vitro

Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min. Staphylococcus epidermidis is the most susceptible of the test organisms, and E. coli and C. albicans are the least susceptible[1].

In Vivo

The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%[1]. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine[2].

Clinical Trial
Molecular Weight

623.83

Formula

C₃₆H₆₄Cl₂N₄

CAS No.

70775-75-6

SMILES

CCCCCCCC/N=C1C=CN(CCCCCCCCCCN(C=C/2)C=CC2=N/CCCCCCCC)C=C/1.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.2 mg/mL (13.14 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6030 mL 8.0150 mL 16.0300 mL
5 mM 0.3206 mL 1.6030 mL 3.2060 mL
10 mM 0.1603 mL 0.8015 mL 1.6030 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[1]

The bactericidal activities of OCT and CHG against Staphylococcus aureus are measured by exposing cultures to several different concentrations of each compound for various lengths of time. OCT is diluted from the 5 mM stock solution and tested in phosphate buffer at levels ranging from 0.5 to 5.0 FsM. The test is begun by adding the bacterial culture to the test solution containing OCT or CHG; samples are taken at 5, 15, 30, and 60 min afterward. The inoculum size is approximately 106 CFU/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Monkeys: Four solutions of OCT are prepared by dissolving OCT in distilled water to final concentrations (wt/wt) of 0.2, 0.4, 0.8 and 1.6%, equivalent to 3.2, 6.4, 12.8 and 25.6 mM, respectively. Skin-degerming activities of aqueous and formulated octenidine and formulated chlorhexidine are compared in single and multiple applications of these agents to the hand and foot surfaces of monkeys by using a glove-juice extraction procedure to measure the skin microflora[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Octenidine dihydrochloride
Cat. No.:
HY-B2170A
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