2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide  (Synonyms: PAR-4-AP; AY-NH2)

製品番号: HY-P1309 純度: 99.75%
COA 取扱説明書 Technical Support

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

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PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide 構造式

CAS 番号 : 352017-71-1

容量 価格（税別） 在庫状況 数量
1 mg $60 在庫あり
5 mg $180 在庫あり
10 mg $300 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of PAR-4 Agonist Peptide, amide:

PAR-4 Agonist Peptide, amide 関連抗体

Top Publications Citing Use of Products

Protease Activated Receptor (PAR) アイソフォーム固有の製品をすべて表示:

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PAR1 PAR2 PAR4

  • 生物活性

  • プロトコル

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

IC50 & Target

PAR-4[1]
体内実験

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

680.79

分子式

C34H48N8O7
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Sequence Shortening

AYPGKF-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (146.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (146.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4689 mL 7.3444 mL 14.6888 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL
10 mM 0.1469 mL 0.7344 mL 1.4689 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献
動物実験
[1]

Mice[1]
SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.4689 mL 7.3444 mL 14.6888 mL 36.7220 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL 7.3444 mL
10 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL
15 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4481 mL
20 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
25 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4689 mL
30 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
40 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
50 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
60 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
80 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
100 mM 0.0147 mL 0.0734 mL 0.1469 mL 0.3672 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PAR-4 Agonist Peptide, amide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAR-4 Agonist Peptide, amide352017-71-1PAR-4-AP AY-NH2Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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製品名:
PAR-4 Agonist Peptide, amide
製品番号:
HY-P1309
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