2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide  (Synonyms: PAR-4-AP; AY-NH2)

Cat. No.: HY-P1309 Purity: 99.75%
COA
SDS
Handling Instructions Technical Support

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide 화학구조

CAS No. : 352017-71-1

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of PAR-4 Agonist Peptide, amide:

PAR-4 Agonist Peptide, amide Related Antibodies

Top Publications Citing Use of Products

View All Protease Activated Receptor (PAR) Isoform Specific Products:

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PAR1 PAR2 PAR4

  • Biological Activity

  • Protocol

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

IC50 & Target

PAR-4[1]
In Vivo

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

680.79

화학식

C34H48N8O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Sequence Shortening

AYPGKF-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

DMSO : 100 mg/mL (146.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (146.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4689 mL 7.3444 mL 14.6888 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서
References
Animal Administration
[1]

Mice[1]
SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

MCE 는 독립적으로 이러한 방법들의 정확성을 확인하지 않았습니다. 참고용으로만 봐주십시오.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.4689 mL 7.3444 mL 14.6888 mL 36.7220 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL 7.3444 mL
10 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL
15 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4481 mL
20 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
25 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4689 mL
30 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
40 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
50 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
60 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
80 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
100 mM 0.0147 mL 0.0734 mL 0.1469 mL 0.3672 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PAR-4 Agonist Peptide, amide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAR-4 Agonist Peptide, amide352017-71-1PAR-4-AP AY-NH2Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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상품명:
PAR-4 Agonist Peptide, amide
Cat. No.:
HY-P1309
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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