2. Neuronal Signaling Membrane Transporter/Ion Channel Epigenetics
  3. Monoamine Oxidase GABA Receptor Histone Demethylase
  4. Phenelzine sulfate

Phenelzine (sulfate)  (Synonyms: 硫酸フェネルジン)

製品番号: HY-B1018A 純度: 99.95%
COA 取扱説明書 Technical Support

Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer.

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Phenelzine sulfate

Phenelzine (sulfate) 構造式

CAS 番号 : 156-51-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
100 mg $60 在庫あり
500 mg $165 在庫あり
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カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of Phenelzine sulfate:

Phenelzine (sulfate) 関連抗体

Top Publications Citing Use of Products

Monoamine Oxidase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MAO-A MAO-B

Histone Demethylase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

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  • 参考文献

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製品説明

Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer[1][2][3][4].

体外実験

Phenelzine sulfate inhibits recombinant mouse MAOA/MAOB, PIPOX, PCYOX1, ALDH2 and SCRN3 proteins[2].
Phenelzine (80 μM; 48 h; H460) sulfate reduces H460 cell proliferation by less than 50% in a [3H]thymidine incorporation assay[3].
Phenelzine (10-100 μM; 24 h; rat retinal ganglion cells) sulfate reduces 3-Aminopropanal-induced toxicity[1].
Phenelzine (150-300 nmol; 30 min; phosphate-buffered saline) sulfate reduces acrolein levels in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenelzine (sulfate) 関連抗体

Cell Cytotoxicity Assay[1]

Cell Line: Rat retinal ganglion cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 100 μM
Incubation Time: 24 h
Result: LDH release was measured 24 hours after cotreatment with 3-Aminopropanal, showing reduced toxicity.

Western Blot Analysis[3]

Cell Line: LNCaP
Concentration: 3 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 48 h
Result: No significant changes in H3K4Me2 or total H3 levels were observed.

Cell Proliferation Assay[3]

Cell Line: H460
Concentration: 80 μM
Incubation Time: 48 h
Result: Less than 50% reduction in 3H-thymidine incorporation.
体内実験

Phenelzine (31.6 mg/kg; drinking water; once daily; 12 weeks) sulfate exhibits lower body fat content, subcutaneous white adipose tissue (WAT) mass and lipid content in skeletal muscles than control, without decreases body weight gain or food consumption[4].
Phenelzine (15 mg/kg; IP, 15 minutes post-injury) sulfate reduces acrolein and 4-HNE levels and improves recovery in a rat spinal cord injury (SCI) model[1].
Phenelzine (aquarium water) sulfate mitigates paraquat-induced neurotoxicity in zebrafish by reducing oxidative stress and preserving dopamine levels and promotes axonal regrowth and remyelination in a zebrafish SCI model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 micEAE was induced in female C57/BL mice with MOG35-55 (HY-P1240)(subcutaneous injection).[5]
Dosage: 15 mg/kg
Administration: IP; daily, for 28 days
Result: Reduced disease severity in the chronic phase and was associated with substantial improvements in exploratory behavior.
Showed a normalization of 5-HT levels in the ventral horn of the spinal cord that might account for the improvements in behavioral outcomes.
Animal Model: Rats; traumatic brain injury (TBI) model, induced by controlled cortical impact (CCI-TBI)[1]
Dosage: 15 mg/kg
Administration: IP; once; 15 minutes post-injury
Result: Prevented the decrease in respiratory control ratio, increased cortical tissue sparing from 86 to 97%, and reduced 4-HNE levels in mitochondria.
Animal Model: Gerbils (male, 8 weeks); global ischemia model, induced by carotid ligation for 5 minutes followed by reperfusion[1]
Dosage: 15 mg/kg, 30 mg/kg
Administration: IP; once daily; 6 days
Result: Significantly attenuated neuronal loss in the hippocampal CA1 region compared to ischemia-vehicle gerbils.
Animal Model: C57BL/6 mice (male, 9 weeks); no disease model[4]
Dosage: 31.6 mg/kg
Administration: Drinking water; once daily; 12 weeks
Result: Exhibited lower body fat content, subcutaneous WAT mass and lipid content in skeletal muscles than control, without decreased body weight gain or food consumption. Phenelzine impaired the lipogenic but not the antilipolytic actions of insulin in WAT.
Lowered MAO activity and hydrogen peroxide release in WAT.
Decreased phosphoenolpyruvate carboxykinase (PEPCK) expression in subcutaneous WAT.
Animal Model: C57BL/6 mice (male, 9 weeks); no disease model[4]
Dosage: 31.6 mg/kg
Administration: Drinking water; once daily; 12 weeks
Result: Lowered non-fasting blood glucose levels.
臨床実験
分子量

234.27

分子式

C8H14N2O4S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

NNCCC1=CC=CC=C1.O=S(O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (426.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2686 mL 21.3429 mL 42.6858 mL
5 mM 0.8537 mL 4.2686 mL 8.5372 mL
10 mM 0.4269 mL 2.1343 mL 4.2686 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (8.88 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (8.88 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.96%

COA (250 KB) HNMR (253 KB) RP-HPLC (241 KB) MS (81 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2686 mL 21.3429 mL 42.6858 mL 106.7145 mL
5 mM 0.8537 mL 4.2686 mL 8.5372 mL 21.3429 mL
10 mM 0.4269 mL 2.1343 mL 4.2686 mL 10.6714 mL
15 mM 0.2846 mL 1.4229 mL 2.8457 mL 7.1143 mL
20 mM 0.2134 mL 1.0671 mL 2.1343 mL 5.3357 mL
25 mM 0.1707 mL 0.8537 mL 1.7074 mL 4.2686 mL
30 mM 0.1423 mL 0.7114 mL 1.4229 mL 3.5571 mL
40 mM 0.1067 mL 0.5336 mL 1.0671 mL 2.6679 mL
50 mM 0.0854 mL 0.4269 mL 0.8537 mL 2.1343 mL
60 mM 0.0711 mL 0.3557 mL 0.7114 mL 1.7786 mL
80 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3339 mL
100 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0671 mL
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Phenelzine sulfate Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenelzine156-51-4Monoamine OxidaseGABA ReceptorHistone DemethylaseMAOGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorlipid contentmonoamine oxidaseChIP-seqcatecholaminesneurotransmitter aminesABPP5-hydroxytryptaminestereochemistrylipid levelscardiac oxidative stresstranylcyprominecancer cellstriacylglycerol turnoverTarget discoverycardiovascular dysfunctionenzymesReactive aldehydesin vitrometabolismglucoseβ-Phenylethylidenehydrazinebody compositionNMRhistone methylationheart rate variabilityneurodegenerative diseasehydrogen peroxideγ-Aminobutyric acidinsulinobesity-associated complicationsnon-selective monoamine oxidase inhibitorstrace aminesmonoamine oxidase inhibitorscardiac sympathovagal balanceChemical proteomicsadipocytesantilipogeniclipogenicantilipolyticnon-fasting blood glucoseoxidative stressantiadipogenicamino acidsbody fatMAO activitywhite adipose tissueSCRN3phosphoenolpyruvate carboxykinaseNeuroprotectionreceptorsLSD1 inhibitorMAO inhibitorHDAC inhibitorsMonoamine oxidasePhenelzine analoguesubcutaneous WATInhibitorinhibitorinhibit

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