Phenelzine-d₅ sulfate

Name: Phenelzine-d 5 sulfate
Brand: MedChemExpress
SKU: HY-B1018AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1018AS Purity: 99%: Data Sheet
COA

SDS
Handling Instructions
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Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer.

For research use only. We do not sell to patients.

Phenelzine-d₅ sulfate Chemical Structure

CAS No. : 1219798-40-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phenelzine-d₅ sulfate:

Phenelzine sulfate In-stock

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•Related Small Molecules:

•Related Proteins:

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms

MAO-A MAO-B

View All Histone Demethylase Isoform Specific Products:

View All Isoforms

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Biological Activity
Purity & Documentation
References
Customer Review

Description

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

239.30

Formula

C₈H₉D₅N₂O₄S

CAS No.

1219798-40-9

Unlabeled CAS

156-51-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(O)(O)=O.NNCCC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (417.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1789 mL	20.8943 mL	41.7886 mL
5 mM	0.8358 mL	4.1789 mL	8.3577 mL
10 mM	0.4179 mL	2.0894 mL	4.1789 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

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Data Sheet (272 KB) SDS (480 KB)

COA (246 KB) HNMR (410 KB) RP-HPLC (450 KB)

Handling Instructions (2659 KB)

References

[1]. Matveychuk D, et al. Overview of the Neuroprotective Effects of the MAO-Inhibiting Antidepressant Phenelzine. Cell Mol Neurobiol. 2022;42(1):225-242. [Content Brief]

[2]. Bustin KA, et al. Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception. Mol Cell Neurosci. 2023;125:103842. [Content Brief]

[3]. Prusevich P, et al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014;9(6):1284-1293. [Content Brief]

[4]. Carpéné C, et al. Body fat reduction without cardiovascular changes in mice after oral treatment with the MAO inhibitor phenelzine. Br J Pharmacol. 2018;175(12):2428-2440. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1789 mL	20.8943 mL	41.7885 mL	104.4714 mL
	5 mM	0.8358 mL	4.1789 mL	8.3577 mL	20.8943 mL
	10 mM	0.4179 mL	2.0894 mL	4.1789 mL	10.4471 mL
	15 mM	0.2786 mL	1.3930 mL	2.7859 mL	6.9648 mL
	20 mM	0.2089 mL	1.0447 mL	2.0894 mL	5.2236 mL
	25 mM	0.1672 mL	0.8358 mL	1.6715 mL	4.1789 mL
	30 mM	0.1393 mL	0.6965 mL	1.3930 mL	3.4824 mL
	40 mM	0.1045 mL	0.5224 mL	1.0447 mL	2.6118 mL
	50 mM	0.0836 mL	0.4179 mL	0.8358 mL	2.0894 mL
	60 mM	0.0696 mL	0.3482 mL	0.6965 mL	1.7412 mL
	80 mM	0.0522 mL	0.2612 mL	0.5224 mL	1.3059 mL
	100 mM	0.0418 mL	0.2089 mL	0.4179 mL	1.0447 mL