2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1939R
    Icariside I (Standard) 56725-99-6 98%
    Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape.
    Icariside I (Standard)
  • HY-N2037R
    Higenamine (Standard) 5843-65-2 98%
    Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases.
    Higenamine (Standard)
  • HY-N2391R
    p-Hydroxycinnamic acid (Standard) 7400-08-0 98%
    p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
    p-Hydroxycinnamic acid (Standard)
  • HY-N2451R
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard) 33037-46-6
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
  • HY-N2609R
    7,4'-Dihydroxyflavone (Standard) 2196-14-7 98%
    7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM.
    7,4'-Dihydroxyflavone (Standard)
  • HY-N4088R
    Pseudolaric acid A-O-β-D-glucopyranoside (Standard) 98891-44-2
    Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities.
    Pseudolaric acid A-O-β-D-glucopyranoside (Standard)
  • HY-N5012R
    Eurycomanone (Standard) 84633-29-4
    Eurycomanone (Standard) is the analytical standard of Eurycomanone. This product is intended for research and analytical applications. Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
    Eurycomanone (Standard)
  • HY-N6678R
    Zearalanone (Standard) 5975-78-0
    Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system.
    Zearalanone (Standard)
  • HY-N6709R
    Zeranol (Standard) 26538-44-3 98%
    Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity.
    Zeranol (Standard)
  • HY-N6974R
    Ascr#2 (Standard) 946524-24-9 98%
    Ascr#2 (Standard) (Ascaroside C6 (Standard)) is the analytical standard of Ascr#2 (HY-N6974). This product is intended for research and analytical applications. Ascr#2 (Ascaroside C6) is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with Ascr#3 (HY-N6977) at low concentration.
    Ascr#2 (Standard)
  • HY-N7104R
    Lactitol (Standard) 585-86-4 98%
    Lactitol (Standard) is the analytical standard of Lactitol (HY-N7104). This product is intended for research and analytical applications. Lactitol (D-Lactitol) is a non-absorbable disaccharide and Bacterial regulator. Lactitol reduces the populations of Bacteroides, Clostridium, coliforms and Eubacterium, while increasing the populations of Lactobacillus and Streptococcus. Lactitol can be used in the research of portosystemic encephalopathy and chronic constipation.
    Lactitol (Standard)
  • HY-N7145R
    Bombykol (Standard) 765-17-3 98%
    Bombykol (Standard) (Isobombycol (Standard)) is the analytical standard of Bombykol (HY-N7145). This product is intended for research and analytical applications. Bombykol is an insect sex pheromone and a sex attractant produced by female Bombyx mandarina.
    Bombykol (Standard)
  • HY-N8593R
    Undecane (Standard) 1120-21-4 98%
    Undecane (Standard) is an analytical standard of Undecane (HY-N8593).Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis.
    Undecane (Standard)
  • HY-P10226
    PGD97 2717490-36-1 98%
    PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis.
    PGD97
  • HY-U00016
    Teoprolol 65184-10-3 98%
    Teoprolol is a β-adrenergic receptor blocker.
    Teoprolol
  • HY-U00018
    (±)-Tazifylline 79712-55-3 98%
    (±)-Tazifylline is a potent, selective and long-acting histamine H1 receptor antagonist.
    (±)-Tazifylline
  • HY-U00019
    Pamatolol 59110-35-9 98%
    Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity.
    Pamatolol
  • HY-U00043
    Triamcinolone Benetonide 31002-79-6 98%
    Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
    Triamcinolone Benetonide
  • HY-U00066
    Cicloprolol hydrochloride 63686-79-3 98%
    Cicloprolol is a partial β 1-adrenoceptor agonist .
    Cicloprolol hydrochloride
  • HY-U00072
    RS-601 207987-59-5 98%
    RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
    RS-601
Cat. No. Product Name / Synonyms Application Reactivity