Icariside I (Standard)
Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 56725-99-6
- Formula: C27H30O11
- Molecular Weight:530.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 56725-99-6
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Molecular Weight 530.52
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Formula C27H30O11
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SMILES
O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=C(C/C=C(C)\C)C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
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Synonyms
Icarisid I (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Hot Topics
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Topics
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Topics Process of PD-1/PD-L1-Mediated Tumor Immune Evasion
PD-1/PD-L1-mediated tumor immune evasion is a central mechanism by which tumors suppress antitumor immunity through immune checkpoint signaling.
2026-06-18
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Topics Escape Route Built by TGF-β Signaling
Escape route built by TGF-β signaling refers to the immunosuppressive and stromal remodeling program through which tumors avoid immune elimination and reduce response to cancer immunotherapy.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Icariside I (Standard) Related Classifications
HY-N1939R Related Classifications
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Keywords
- Icariside I (Standard)
- 56725-99-6
- Icarisid I (Standard)
- Reference Standards
- Apoptosis
- Reactive Oxygen Species (ROS)
- NOD-like Receptor (NLR)
- STAT
- CDK
- Bcl-2 Family
- Aryl Hydrocarbon Receptor
- JAK
- Caspase
- IFNAR
- PD-1/PD-L1
- Cyclin dependent kinase
- AhR
- Janus kinase
- Interferon-α/β receptor
- Interferon-alpha/beta receptor
- PD-1/Programmed death-ligand 1
- BMDMs
- BMMs
- IDILI
- 4T1-luc cells
- OVX
- osteoporosis mouse
- Inhibitor
- inhibitor
- inhibit