Higenamine (Standard)
Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases.
For research use only. We do not sell to patients.
- CAS No.: 5843-65-2
- Formula: C16H17NO3
- Molecular Weight:271.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 5843-65-2
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Molecular Weight 271.31
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Formula C16H17NO3
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SMILES
OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O
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Synonyms
Norcoclaurine (Standard); Demethyl-Coclaurine (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Higenamine (Standard) Related Classifications
HY-N2037R Related Classifications
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Keywords
- Higenamine (Standard)
- 5843-65-2
- Norcoclaurine (Standard)
- Demethyl-Coclaurine (Standard)
- Reference Standards
- MAP3K
- MDM-2/p53
- Adrenergic Receptor
- ROS Kinase
- Apoptosis
- MAP kinase kinase kinase, MEKK, MAPKKK
- Beta Receptor
- β2-AR
- heart failure
- myocyte
- ischemia/reperfusion
- myocardial infarction
- osteoporosis
- Leukemia
- MV4-11
- MOLM-13
- stroke
- CRS
- C6
- HNPCs
- BMSCs
- Inhibitor
- inhibitor
- inhibit