2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120154
    Palitantin 15265-28-8 98%
    Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis.
    Palitantin
  • HY-120183
    Harzianopyridone 137813-88-8 98%
    Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities.
    Harzianopyridone
  • HY-120185
    Saintopin 131190-63-1 98%
    Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage.
    Saintopin
  • HY-120190
    Citreoindole 138655-14-8 98%
    Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM.
    Citreoindole
  • HY-120288
    AM4299B 160825-49-0 98%
    AM4299B is an inhibitor for thiol protease. AM4299B inhibits bovine spleen cathepsin B, human kidney cathepsin L and papain with IC50s of 0.7, 0.5 and 20 μM, respectively. AM4299B can be used in research in osteoporosis, and has potential to be used as an antiparasitic agent.
    AM4299B
  • HY-120315
    Nyssoside 182138-70-1 98%
    Nyssoside, a ellagic acid derivative, has significant antioxidant activity and shows antibacterial activity against different pathogenic bacteria.
    Nyssoside
  • HY-120331
    U-89360E 161897-65-0 98%
    U-89360E is an inhibitor for HIV-1 protease. U-89360E inhibits the protease of HIV-1 wildtype, V82D mutant and V82N mutant with Ki of 20 nM, 560 nM and 2100 nM, respectively.
    U-89360E
  • HY-120333
    Antibiotic PF 1052 147317-15-5 98%
    Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration.
    Antibiotic PF 1052
  • HY-120382
    LY 215890 153502-35-3 98%
    LY 215890 ia an orally active antibacterial agent aganist Escherichia coli EC14 and Klebsiella pneumonia X26.
    LY 215890
  • HY-120390
    L 694746 139934-80-8 98%
    L 694746 is the metabolite of L-689502 (HY-U00261). L 694746 is an inhibitor for HIV-1 protease with an IC50 of 1 nM and a Ki of 0.34 nM.
    L 694746
  • HY-120432
    CaMdr1p-IN-1 1257542-38-3 98%
    CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM.
    CaMdr1p-IN-1
  • HY-120465
    ZINC36617540 1174905-91-9 98%
    ZINC36617540 is a novel Nef protein inhibitor with anti-HIV activity. ZINC36617540 exhibits superior binding affinity by binding to Nef protein. ZINC36617540 shows a similar binding mode to the prototype molecule B9 in molecular docking. The mechanism of action of ZINC36617540 mainly depends on its hydrophobic and electrostatic interactions with Nef protein.
    ZINC36617540
  • HY-120489
    A110 1185388-35-5 98%
    A110 is the inhibitor for Cryptosporidium parvum inosine monophosphate dehydrogenase (CpIMPDH). A110 inhibits CpIMPDH in Toxoplasma gondii with IC50 of 18 nM. A110 exhibits pro-parasitic efficacy and cause parasitemia.
    A110
  • HY-120607
    Chevalone C 1318025-77-2 98%
    Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines.
    Chevalone C
  • HY-120634
    BMS-929075 1217338-97-0 98%
    BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity.
    BMS-929075
  • HY-120733
    Calpinactam 1205538-83-5 98%
    Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively.
    Calpinactam
  • HY-120764
    PF-46396 1207481-21-7 98%
    PF-46396 is a potent HIV-1 inhibitor with an EC50 value of 0.206 µM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle.
    PF-46396
  • HY-120812
    HIV-IN-11 160729-91-9 98%
    HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor.
    HIV-IN-11
  • HY-120827
    Allosamidin 103782-08-7 98%
    Allosamidin (A82516) is an insect chitinase inhibitor with an IC50 of 0.35 μM against Bombyx mori chitinase.
    Allosamidin
  • HY-120880
    SKF107457 126333-28-6 98%
    SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research.
    SKF107457
Cat. No. Product Name / Synonyms Application Reactivity