2. Anti-infection
  3. HCV
  4. BMS-929075

BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity.

For research use only. We do not sell to patients.

BMS-929075 Chemical Structure

BMS-929075 Chemical Structure

CAS No. : 1217338-97-0

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Based on 1 publication(s) in Google Scholar

BMS-929075 Related Antibodies

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Description

BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity[1].

In Vitro

BMS-929075 (0-60 µM) shows cytotoxicity with CC50 values of 60, >12.5, >50 µM for Huh-7, HepG2, primary human hepatocytes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-929075 Related Antibodies
In Vivo

BMS-929075 (compound 37) (2 mg/kg for i.v.; 6 mg/kg for p.o.) shows good pharmacokinetic parameters with oral bioavailability of 48% in rats[1].
Pharmacokinetic Parameters of BMS-929075 in Male Sprague-Dawley rats[1].

IV PO
species Cl (mL/min/kg) IV t1/2(hr) Vss(L/kg) Cmax(µM) Tmax(hr) AUC (µM h) C6 liver (µM) C24 liver (µM) C24 liver/plasma (µM) F% (mL/min/kg)
rat 1.7 4.7 0.7 7.5 4 54.5 15.1 1.12 1.6 48
Rats, 2 mg/kg i.v.; 6 mg/kg p.o.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

538.54

Formula

C31H24F2N4O3
CAS No.
SMILES

O=C(C1=CC(C2=C(F)C3=C(OC(C4=CC=C(F)C=C4)=C3C(NC)=O)C=C2)=C(C)C=C1)NC5(CC5)C6=NC=CC=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-929075 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9290751217338-97-0BMS929075BMS 929075HCVHepatitis C virusorally activecytotoxicityHuh-7HepG2 cellsInhibitorinhibitorinhibit

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