2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-151552
    Mtb-cyt-bd oxidase-IN-5 98%
    Mtb-cyt-bd oxidase-IN-5 (compound 1k) is a Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC50 value of 0.37 μM. Mtb-cyt-bd oxidase-IN-5 can effectively inhibit the growth of Mtb (MIC= 256 μM). Mtb-cyt-bd oxidase-IN-5 can be used in the study of tuberculosis.
    Mtb-cyt-bd oxidase-IN-5
  • HY-151553
    Mtb-cyt-bd oxidase-IN-6 1246461-10-8 98%
    Mtb-cyt-bd oxidase-IN-6 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC50 value of 0.35 μM. Mtb-cyt-bd oxidase-IN-6 can effectively inhibit the growth of Mtb (MIC= 4 μM). Mtb-cyt-bd oxidase-IN-6 can be used in the study of tuberculosis.
    Mtb-cyt-bd oxidase-IN-6
  • HY-151555
    Antifungal agent 44 98%
    Antifungal agent 44 (compound 2A-5) is an antifungal agent, and shows excellent fungicidal activity superior to Kresoxim-methyl (HY-125776). Antifungal agent 44 shows fungicidal activity against Phytophthora capsici most remarkably, with an EC50 value of about 5 μM.
    Antifungal agent 44
  • HY-151556
    Antifungal agent 45 98%
    Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC50 value of about 5 μM.
    Antifungal agent 45
  • HY-151566
    Antifungal agent 46 2842067-19-8 98%
    Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase.
    Antifungal agent 46
  • HY-151567
    Antibacterial agent 123 2615254-55-0 98%
    Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.
    Antibacterial agent 123
  • HY-151575
    PfGSK3/PfPK6-IN-2 2797225-47-7 98%
    PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria.
    PfGSK3/PfPK6-IN-2
  • HY-151581
    HCVcc-IN-1 2977251-08-2 98%
    HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity.
    HCVcc-IN-1
  • HY-151589
    HCVcc-IN-2 2977251-02-6 98%
    HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498).
    HCVcc-IN-2
  • HY-151598
    Pks13-TE inhibitor 2 3031462-75-3 98%
    Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.
    Pks13-TE inhibitor 2
  • HY-151599
    Pks13-TE inhibitor 3 3031462-62-8 98%
    Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.
    Pks13-TE inhibitor 3
  • HY-151608
    SARS-CoV-2 Mpro-IN-3 3031351-76-2 98%
    SARS-CoV-2 Mpro-IN-3 is a potent Mpro inhibitor with an IC50 value of ﹥5 μM. SARS-CoV-2 Mpro-IN-3 can be used in research of COVID-19.
    SARS-CoV-2 Mpro-IN-3
  • HY-151612
    Anti-infective agent 6 2839192-35-5 98%
    Anti-infective agent 6 (compound 28) is a potent anti-infectious agent. Anti-infective agent 6 shows a good activity against P. falciparum F32-ART (IC50=1.4 μM) with a good selectivity index (SI>36). Anti-infective agent 6 also shows a potency against L. donovani (IC50=3.5 μM).
    Anti-infective agent 6
  • HY-151614
    Anti-infective agent 7 2839192-25-3 98%
    Anti-infective agent 7 is a potent anti-infectious agent. Anti-infective agent 7 has anti-infection activity against P. falciparum (IC50=2.5 μM) and M. tuberculosis (MIC=9 μM).
    Anti-infective agent 7
  • HY-151631
    MRV03-070 2797066-20-5 98%
    MRV03-070 is an inhibitor of colibactin-activating peptidase ClbP with an IC50 value of 69 nM, acts like biosynthetic precursor precolibactin.
    MRV03-070
  • HY-151806
    HadAB-IN-1 1097120-47-2 98%
    HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC50 value of 0.03 μM. HadAB-IN-1 also affects mycolic acid biosynthesis in Mycobacterium tuberculosis (Mtb). HadAB-IN-1 can be used for the research of tuberculosis (TB).
    HadAB-IN-1
  • HY-151875
    MurA-IN-3 2866186-38-9 98%
    MurA-IN-3 is a reversible pyrrolidinedione-based MurA inhibitor. MurA-IN-3 has inhibitory activity for MurA with an IC50 value of 4.5 μM. MurA-IN-3 also has antibacterial activity.
    MurA-IN-3
  • HY-151880
    Antibacterial agent 124 2304448-00-6 98%
    Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS).
    Antibacterial agent 124
  • HY-151900
    SARS-CoV-2 Mpro-IN-4 98%
    SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 8.2 nM.
    SARS-CoV-2 Mpro-IN-4
  • HY-151901
    SARS-CoV-2 Mpro-IN-5 3023276-79-8 98%
    SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 14.7 nM.
    SARS-CoV-2 Mpro-IN-5
Cat. No. Product Name / Synonyms Application Reactivity