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Cat. No.: HY-151575

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PfGSK3/PfPK6-IN-2

PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC₅₀: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria.

For research use only. We do not sell to patients.

CAS No.: 2797225-47-7
Formula: C₂₄H₂₅Cl₂N₅OS
Molecular Weight:502.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PfGSK3/PfPK6-IN-2 Chemical Structure

CAS No.: 2797225-47-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Plasmodium falciparum GSK3/PK6 (PfGSK3/PfPK6)^[1]

All GSK-3 Isoforms :

In Vitro

PfGSK3/PfPK6-IN-2 (compound 23d) inhibits P. falciparum 3D7 load in erythrocytes (EC₅₀: 552 nM)^[1].
PfGSK3/PfPK6-IN-2 (2 μM) shows cytotoxicity against HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2797225-47-7
Molecular Weight 502.46
Formula C₂₄H₂₅Cl₂N₅OS
SMILES

O=C(C1=CC=C(NC2=NC=C(Cl)C(C3=CC=C(Cl)S3)=N2)C=C1)N4CCC(N5CCCC5)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65(19):13172-13197. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PfGSK3/PfPK6-IN-2

All GSK-3 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PfGSK3/PfPK6-IN-2 Related Classifications

HY-151575 Related Classifications