Pks13-TE inhibitor 2
Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.
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- No. CAS: 3031462-75-3
- Fòrmula: C22H19NO5
- Peso molecular:377.39
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
IC50: 1.30 µM (Pks13-TE)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
0.125 μg/mL
Compound: 32
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 36174223] |
In Vitro
Pks13-TE inhibitor 2 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0039-0.0078 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:DS (drug-susceptible Mtb strain)-tuberculosis (V4207), MDR (multidrug-resistant strain of Mtb, resistance to isoniazid and rifampin)-tuberculosis (V2475 and KZN494), XDR (extensively drug-resistant strain of Mtb resistant to isoniazid, rifampin, levofloxacin ofloxacin, and kanamycin)-tuberculosis (TF274 and R506) strains
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Concentration:0-5.43 µM (0-2048 µg/mL)
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Incubation Time:7 days
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Result:Inhibited V4207/DS Mtb strain (MIC=0.0078 µg/mL) and the MIC values for V2475/MDR, KZN494/MDR, TF274/XDR and R506/XDR Mtb strains were 0.0039 µg/mL.
Chemical Information
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No. CAS 3031462-75-3
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Peso molecular 377.39
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Fòrmula C22H19NO5
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SMILES
O=C(C1=C2OC3=CC=C(OCN(C4CCCC4)C5)C5=C31)OC6=C2C=CC(O)=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pks13-TE inhibitor 2 Related Classifications
HY-151598 Related Classifications
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