Pks13-TE inhibitor 2
Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.
For research use only. We do not sell to patients.
- CAS No.: 3031462-75-3
- Formula: C22H19NO5
- Molecular Weight:377.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.30 µM (Pks13-TE)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
0.125 μg/mL
Compound: 32
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 36174223] |
Pks13-TE inhibitor 2 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0039-0.0078 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DS (drug-susceptible Mtb strain)-tuberculosis (V4207), MDR (multidrug-resistant strain of Mtb, resistance to isoniazid and rifampin)-tuberculosis (V2475 and KZN494), XDR (extensively drug-resistant strain of Mtb resistant to isoniazid, rifampin, levofloxacin ofloxacin, and kanamycin)-tuberculosis (TF274 and R506) strains
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Concentration:0-5.43 µM (0-2048 µg/mL)
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Incubation Time:7 days
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Result:Inhibited V4207/DS Mtb strain (MIC=0.0078 µg/mL) and the MIC values for V2475/MDR, KZN494/MDR, TF274/XDR and R506/XDR Mtb strains were 0.0039 µg/mL.
Chemical Information
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CAS No. 3031462-75-3
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Molecular Weight 377.39
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Formula C22H19NO5
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SMILES
O=C(C1=C2OC3=CC=C(OCN(C4CCCC4)C5)C5=C31)OC6=C2C=CC(O)=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pks13-TE inhibitor 2 Related Classifications
HY-151598 Related Classifications
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