SARS-CoV-2 Mpro-IN-5
SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 14.7 nM.
For research use only. We do not sell to patients.
- CAS No.: 3023276-79-8
- Formula: C34H43FN4O7
- Molecular Weight:638.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MPro/CatL[1]
SARS-CoV-2 Mpro-IN-5 (SM142) blocks SARS-CoV2 replication in A549-hACE2 cells with IC50 value of 14.7 nM[1].
SARS-CoV-2 Mpro-IN-5 (0-50 μM, 24 h) cause cytotoxicity in A549-hACE2 cells[1].
SARS-CoV-2 Mpro-IN-5 inhibits OC-43 virus mRNA expression A549 cells[1].
SARS-CoV-2 Mpro-IN-5 inhibits SARS-CoV2 infection by inhibiting both MPro and CatL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549-hACE2 cells
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Concentration:0, 0.1, 0.2, 2, 20, 50 μM
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Incubation Time:24 h
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Result:Dose-dependently inhibited cell viability, reduce by 15% at 50 μM.
SARS-CoV-2 Mpro-IN-5 (3 mg/kg, i.v.) shows a half-life of 2.1 h and high clearance of 18490 mL/min/kg in in male C57Bl/6 mice[1].
SARS-CoV-2 Mpro-IN-5 (10 mg/kg, p.o.) shows oral bioavailability of 37.5%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:K18-hACE2 transgenic mice[1]
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Dosage:10 mg/kg (i.n.) or 25 mg/kg (i.p.)
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Administration:Intranasal inhalation (i.n.), once daily for 3 days, prior to the infection; or Intraperitoneal injection (i.p.), twice daily for 5 days, postinfection administration.
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Result:Prevented weight loss and prolonged survival.
Chemical Information
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CAS No. 3023276-79-8
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Molecular Weight 638.73
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Formula C34H43FN4O7
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SMILES
O=C([C@H](NC(OC(C)(C)C)=O)CC1=CC=C(F)C=C1)N[C@H](C(N[C@@H](C[C@@H]2CCNC2=O)/C=C/C(OCC)=O)=O)CC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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