Pks13-TE inhibitor 3
Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.
For research use only. We do not sell to patients.
- CAS No.: 3031462-62-8
- Formula: C21H18FNO5
- Molecular Weight:383.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 1.55 µM (Pks13-TE)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
4 μg/mL
Compound: 23
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 36174223] |
In Vitro
Pks13-TE inhibitor 3 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0625-0.25 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:DS (drug-susceptible Mtb strain)-tuberculosis (V4207), MDR (multidrug-resistant strain of Mtb, resistance to isoniazid and rifampin)-tuberculosis (V2475 and KZN494), XDR (extensively drug-resistant strain of Mtb resistant to isoniazid, rifampin, levofloxacin ofloxacin, and kanamycin)-tuberculosis (TF274 and R506) strains
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Concentration:0-5.43 µM (0-2048 µg/mL)
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Incubation Time:7 days
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Result:Inhibited V4207/DS Mtb strain (MIC=0.125 µg/mL), V2475/MDR (MIC=0.125-0.25 µg/mL), KZN494/MDR (MIC=0.0625-0.125 µg/mL), TF274/XDR (MIC=0.0625 µg/mL) and R506/XDR (MIC=0.0625 µg/mL) Mtb strains.
Chemical Information
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CAS No. 3031462-62-8
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Molecular Weight 383.37
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Formula C21H18FNO5
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SMILES
O=C1C2=C(OC3=CC=C(O)C(CN4CCC(F)CC4)=C32)C5=C(O1)C=C(O)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pks13-TE inhibitor 3 Related Classifications
HY-151599 Related Classifications
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