Pks13-TE inhibitor 3
Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.
For research use only. We do not sell to patients.
- CAS No.: 3031462-62-8
- Formula: C21H18FNO5
- Molecular Weight:383.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.55 µM (Pks13-TE)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
4 μg/mL
Compound: 23
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 36174223] |
Pks13-TE inhibitor 3 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0625-0.25 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DS (drug-susceptible Mtb strain)-tuberculosis (V4207), MDR (multidrug-resistant strain of Mtb, resistance to isoniazid and rifampin)-tuberculosis (V2475 and KZN494), XDR (extensively drug-resistant strain of Mtb resistant to isoniazid, rifampin, levofloxacin ofloxacin, and kanamycin)-tuberculosis (TF274 and R506) strains
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Concentration:0-5.43 µM (0-2048 µg/mL)
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Incubation Time:7 days
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Result:Inhibited V4207/DS Mtb strain (MIC=0.125 µg/mL), V2475/MDR (MIC=0.125-0.25 µg/mL), KZN494/MDR (MIC=0.0625-0.125 µg/mL), TF274/XDR (MIC=0.0625 µg/mL) and R506/XDR (MIC=0.0625 µg/mL) Mtb strains.
Chemical Information
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CAS No. 3031462-62-8
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Molecular Weight 383.37
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Formula C21H18FNO5
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SMILES
O=C1C2=C(OC3=CC=C(O)C(CN4CCC(F)CC4)=C32)C5=C(O1)C=C(O)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pks13-TE inhibitor 3 Related Classifications
HY-151599 Related Classifications
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