3031462-62-8
Chemical Structure
Pks13-TE inhibitor 3
- CAS No.: 3031462-62-8
- Formula:C21H18FNO5
- Molecular Weight:383.37
IUPAC Name: 7-((4-fluoropiperidin-1-yl)methyl)-3,8-dihydroxy-6H-benzofuro[3,2-c]chromen-6-one
InChIKey: LGQUGSNVIXYSKO-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC3=CC=C(O)C(CN4CCC(F)CC4)=C32)C5=C(O1)C=C(O)C=C5
Biological Activity: Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB[1].
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Pks13-TE inhibitor 3 | Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB. | |||||||||||||||||||||
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Keywords
