HCVcc-IN-2

HCVcc-IN-2 (compound 6c) (0.1, 1, 10, and 100 μg/mL; 1 h) shows antiviral activities against a variety of viruses such as coxsackievirus B4 (CBV4), hepatitis A virus HM 175 (HAV), hepatitis C genotype 4 (HCVcc), adenovirus type 7 (HAdV7), and herpes simplex virus 1 (HSV-1) with viral reduction rates of 83.3%, 63.3%, 40%, 63.3%, and 30%, respectively^[1].
HCVcc-IN-2 (0.55-1.9 μg/mL; 1 h) inhibits various virus with IC₅₀ of 0.55 μg/mL (herpes simplex virus), 0.76 μg/mL (HCVcc genotype virus), and 0.76 μg/mL (coxsackievirus B4), respectively; or with CC₅₀ of 1.8 μg/mL (herpes simplex virus), 1.9 μg/mL (HCVcc genotype virus), and 1.9 μg/mL (coxsackievirus B4), respectively^[1].
HCVcc-IN-2 (7.68-16.01 μg/mL; ) inhibits hepatitis C virus NS3/4A and HSV- USP7 protease enzyme with IC₅₀s of 16.01 μg/mL and 7.68 μg/mL^[1].
HCVcc-IN-2 (0.01 mM; 24 h) has low cytotoxicity, shows high inhibition against two cell lines, SK-MEL-5, OVCAR-4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.