2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-157840
    Anti-infective agent 9 758689-17-7 98%
    Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor (IC50=600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium. Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS).
    Anti-infective agent 9
  • HY-157870
    Mtb-IN-6 98%
    Mtb-IN-6 (Compound C10) is a Mycobacterium tuberculosis(Mtb) respiration inhibitor. Mtb-IN-6 can enhance the bactericidal activity of isoniazid (INH, HY-B0329). Mtb-IN-6 inhibits WT Mtb with an IC50 of 25 µM.
    Mtb-IN-6
  • HY-157933
    SF-C5-TPP 98%
    SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM>[1].
    SF-C5-TPP
  • HY-157940
    Methylsolfonyl 25(S)-Δ7-dafachronic acid 98%
    Methylsolfonyl 25(S)-Δ7-dafachronic acid (compound 3) is a selective ssDAF-12 agonist with the IC50 of 0.41 μM. Methylsolfonyl 25(S)-Δ7-dafachronic acid shows low cell cytotoxicity in HepG2 cells with IC50 of >200 μM. Methylsolfonyl 25(S)-Δ7-dafachronic acid can be used for study of parasitism.
    Methylsolfonyl 25(S)-Δ7-dafachronic acid
  • HY-157966
    SARS-CoV-2 3CLpro-IN-23 98%
    SARS-CoV-2 3CLpro-IN-23 (Compound Cd3) is a compound that can be isolated from Citrus depressa. SARS-CoV-2 3CLpro-IN-23 has good inhibitory activity to the SARS-CoV-2 spike protein, with KD of 0.79 μM. SARS-CoV-2 3CLpro-IN-23 can bind to key amino acid residue, disrupting the formation of the spike protein and h-ACE2 complex.
    SARS-CoV-2 3CLpro-IN-23
  • HY-157987
    MBX3135 1636878-36-8 98%
    MBX3135 is an efflux pump inhibitor which can enhance the effect of antibiotics through the AcrB target of bacteria. MBX3135 can be used for research of infection and antibiotics.
    MBX3135
  • HY-158003
    COE-PNH2 98%
    COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC90 of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity.
    COE-PNH2
  • HY-158022
    CTSL/CAPN1-IN-1 98%
    CTSL/CAPN1-IN-1 (compound 14a) is an oral active CTSL and CAPN1 inhibitor with the IC50  values of 3.34 nM and 375.1 nM for CTSL and CAPN1, respectively. CTSL/CAPN1-IN-1 shows anticoronaviral activity and anti-inflammatory effect.
    CTSL/CAPN1-IN-1
  • HY-158046
    UNC8899 98%
    UNC8899 is a VHL-recruiting STING PROTAC degrader (DC50: 0.0.924 μM). UNC8899 can be used for viral or bacterial infection research (Blue: VHL ligand, Black: linker; Pink: STING inhibitor).
    UNC8899
  • HY-158047
    UNC8900 98%
    UNC8900 is a VHL recruiting STING PROTAC degrader (DC50: 0.0.924 μM). UNC8900 can be used for research of viral or bacterial infection. (Blue: VHL ligand, black: linker; Pink: STING inhibitor).
    UNC8900
  • HY-158053
    Antifungal agent 94 3030502-21-4 98%
    Antifungal agent 94 (Compound 49) is a Flavonoid derivative, which exhibits antifungal activity with EC50 of 0.28 μM and a half-maximal effective concentration of 0.46 μg/mL against Rhizoctonia solani.
    Antifungal agent 94
  • HY-158054
    Antifungal agent 95 2883716-51-4 98%
    Antifungal agent 95 (Compound CN21b) is an antifungal agent for Sclerotinia sclerotiorum and Botrytis cinerea, with EC50s of 2.11 and 0.97 μM, respectively. Antifungal agent 95 exhibits antifungal activity against resistant B. cinerea strains, with EC50s less than 10 μM.
    Antifungal agent 95
  • HY-158060
    MC2646 98%
    MC2646 is a potent anti-parasite agent. MC2646 induces autophagic. MC2646 activates the AMPK/TFEB pathway.
    MC2646
  • HY-158073
    ML2006a4 2943213-62-3 98%
    ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (Mpro) with IC50 in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level
    ML2006a4
  • HY-158120
    LasR agonist 1 98%
    LasR agonist 1 (9) is a LasR agonist, with an EC50 of 0.7 μM. Used for P. aeruginosa research.
    LasR agonist 1
  • HY-158124
    LasR antagonist 1 1421464-74-5 98%
    LasR antagonist 1 (Compound 7) is an antagonist for LasR with an IC50 of 0.4 μM, that modulates the quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa.
    LasR antagonist 1
  • HY-158141
    BRD1401 98%
    BRD1401 is a small molecule targeting the outer membrane protein OprH. BRD1401 disrupts the interaction of OprH with LPS. BRD1401 can increase membrane fluidity.
    BRD1401
  • HY-158241
    GmhA-IN-1 1606387-54-5 98%
    GmhA-IN-1 (compound 17) is an inhibitor of GmhA with an IC50 value of 2.4 nM. GmhA-IN-1 enhances the activity of erythromycin and rifampicin on wild-type E. coli.
    GmhA-IN-1
  • HY-158242
    Antibacterial agent 212 98%
    Antibacterial agent 212 (Compound 162) is an antibacterial agent with oral activity and good pharmacokinetic properties, having a MIC of 4 μg/mL against Pseudomonas aeruginosa T-2022-D2-048.
    Antibacterial agent 212
  • HY-158258
    Antiviral agent 55 371137-60-9
    Antiviral agent 55 (Compound 107) is an inhibitor for human immunodeficiency virus 1 and 2 (HIV 1 and HIV 2), and exhibits antiviral activity.
    Antiviral agent 55
Cat. No. Product Name / Synonyms Application Reactivity