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Cat. No.: HY-157987

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MBX3135

MBX3135 is an efflux pump inhibitor which can enhance the effect of antibiotics through the AcrB target of bacteria. MBX3135 can be used for research of infection and antibiotics.

For research use only. We do not sell to patients.

CAS No.: 1636878-36-8
Formula: C₂₈H₃₄N₄O₃S
Molecular Weight:506.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

MBX3135 Chemical Structure

CAS No.: 1636878-36-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MBX3135 is an efflux pump inhibitor which can enhance the effect of antibiotics through the AcrB target of bacteria. MBX3135 can be used for research of infection and antibiotics^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	CC₅₀	62.4 μM Compound: 22i	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 25818767]

In Vitro

MBX3135 (0.024-0.39 μM, 4 h) potentiates the bactericidal activity of a minimally bactericidal dose of ciprofloxacin (0.01 μg/mL) against E. coli^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1636878-36-8
Molecular Weight 506.66
Formula C₂₈H₃₄N₄O₃S
SMILES

C=CC(NC1=CC=C(C=C1)CCSC2=NC(N3CC(OC(C3)C)C)=C4COC(C)(CC4=C2C#N)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sjuts H, et al. Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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