COE-PNH2 

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC₉₀ of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity^[1].

COE-PNH2 (0-128 μg/mL) exhibits a stable antibacterial activity and extreme antibiotic tolerance against intracellular, replicating and nutrient-starved, non-replicating Mab^[1].
COE-PNH2 exhibits a low propensity for resistance development with consistent MIC values in 14 passages of Mab^[1].
COE-PNH2 (0-64 μg/mL) induces a depletion of ATP, accumulation of intracellular lipid inclusions (ILIs) and bacterial elongation in Mab^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COE-PNH2 (2.5-5 mg/kg, intratracheal, every other day for 12 days) exhibits well tolerance and efficiency in acute lung infection in C3HeB/FeJ mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1207.03

C₅₄H₉₈Cl₈N₈O₄

C[N+](C)(CCCN)CCCOC1=CC(/C=C/C2=CC=C(/C=C/C3=CC(OCCC[N+](C)(CCCN)C)=CC(OCCC[N+](C)(CCCN)C)=C3)C=C2)=CC(OCCC[N+](C)(CCCN)C)=C1.[Cl-].[Cl-].[Cl-].[Cl-].Cl.Cl.Cl.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang K, et al., An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus. Sci Transl Med. 2024 Feb 21;16(735):eadi7558.  [Content Brief]