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Cat. No.: HY-158060

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MC2646

MC2646 is a potent anti-parasite agent. MC2646 induces autophagic. MC2646 activates the AMPK/TFEB pathway.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₀N₂O
Molecular Weight:316.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

MC2646 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MC2646 is a potent anti-parasite agent. MC2646 induces autophagic. MC2646 activates the AMPK/TFEB pathway^[1].

All Parasite Isoforms :

In Vitro

MC2646 (4 µM; 24 h) induces autophagic flux by increases the LC3-II:LC3-I ratio ^[1].
MC2646 (4 µM; 24 h) increases the expression of p-AMPK and increase in the nuclear:cytoplasmic TFEB localization^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

TBL3, BL3 cells
Concentration:

4 µM
Incubation Time:

24 h
Result:

Increased the LC3-II:LC3-I ratio in infected TBL3 and uninfected BL3 cells,

Chemical Information

Molecular Weight 316.40
Formula C₂₁H₂₀N₂O
SMILES

NC1CC1C2=CC=C(C=C2)NC(CC3=CC4=CC=CC=C4C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Villares M, et al. Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy. Nat Commun. 2024 Mar 12;15(1):2235. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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MC2646

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MC2646 Related Classifications

HY-158060 Related Classifications