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  4. Anti-infective agent 9

Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor (IC50=600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium. Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS).

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Anti-infective agent 9 Chemical Structure

Anti-infective agent 9 Chemical Structure

CAS No. : 758689-17-7

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Description

Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor (IC50=600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium. Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS)[1].

IC50 & Target

IC50: 600 nM (P. falciparum)[1]
Molecular Weight

356.39

Formula

C14H11F3N4S2
CAS No.
SMILES

CC1=C(SC(N)=N1)C2=CSC(NC3=CC=C(C=C3)C(F)(F)F)=N2
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Anti-infective agent 9 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-infective agent 9758689-17-7ParasiteDXPSMEP pathwayPlasmodium falciparumPolypharmacologymalariaInhibitorinhibitorinhibit

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