2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-163617
    c-PB2(OH)2 98%
    c-PB2(OH)2 is a 4-carboxyphenyl / 4-hydroxyphenyl meso-substituted porphyrin compound. c-PB2(OH)2 shows anti HIV-1 activity under non-photodynamic and photodynamic conditions.
    c-PB2(OH)2
  • HY-163621
    Cap-dependent endonuclease-IN-28 98%
    Cap-dependent endonuclease-IN-28 (Compound 11) is a potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-28 inhibits CEN of TOSV, ANDV, and LACV viruses with IC50 values ​​of 2.4, 0.5, and 4 μM, respectively.
    Cap-dependent endonuclease-IN-28
  • HY-163630
    Antibacterial agent 217 3040034-03-2 98%
    Antibacterial agent 217 (Compound 24) is a non-cytotoxic, non-hemolytic, moderately active antibacterial agent that inhibits the growth of Staphylococcus aureus strains with a minimum inhibitory concentration (MIC) of 32 μg/mL. Antibacterial agent 217 also moderately inhibits the growth of Staphylococcus epidermidis.
    Antibacterial agent 217
  • HY-163670
    TLR7 agonist 21 3040038-00-1 98%
    TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections.
    TLR7 agonist 21
  • HY-163700
    Fabl inhibitor 1 98%
    Fabl inhibitor 1 (Compound (S)-n31) is an orally active and potent SaFabI inhibitor (IC50 = 94.0 nM, MIC = 0.25-1 μg/mL). Fabl inhibitor 1 can be used for the research of methicillin-resistant S. aureus (MRSA) infection.
    Fabl inhibitor 1
  • HY-163706
    SARS-CoV-2-IN-88 98%
    SARS-CoV-2-IN-88 (compound 3a) is a potent SARS-CoV-2 inhibitor with inhibitory value of 96.00%.
    SARS-CoV-2-IN-88
  • HY-163708
    Antibacterial agent 98%
    Antibacterial agent (compound 8b) is a potent antibacterial agent. Antibacterial agent shows robust antibacterial efect on E. coli and S. aureus with IC50s of 64 and 32 µg/mL, respectively.
    Antibacterial agent
  • HY-163762
    Antibacterial agent 226 2801577-35-3 98%
    Antibacterial agent 226 (Compound 7f) is an antibacterial agent, that inhibits Staphylococcus aureus strains and methicillin-resistant S. aureus strain with MIC of 2 μg/mL. Antibacterial agent 226 exhibits cytotoxicity to HEK293 with IC50 of 1.9 μM.
    Antibacterial agent 226
  • HY-163765
    Antimalarial agent 41 98%
    Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models.
    Antimalarial agent 41
  • HY-163773
    JNJ-7950 3051902-04-3 99.88%
    JNJ-7950 (compound 5c) exhibits antiviral activity against RSV with an EC50 value of 0.78 nM. JNJ-7950 can be used in the study of respiratory tract infections.
    JNJ-7950
  • HY-163785
    1"-α-Azido-RDPr 98%
    1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain SARS-CoV-2 NSP3 Mac1 with an IC50 of 30 nM.
    1
  • HY-163852
    HIV-1 inhibitor-72 2801703-79-5 98%
    HIV-1 inhibitor-72 (compound 5m) is a target protein ligand of PROTAC Vif degrader-1 (HY-163851). HIV-1 inhibitor-72 is a potent HIV-1 inhibitor.
    HIV-1 inhibitor-72
  • HY-163857
    SARS-CoV-2-IN-91 98%
    SARS-CoV-2-IN-91 (Compound 194) is an inhibitor for SARS-CoV 2 with an EC50 of 28.92 μM. SARS-CoV-2-IN-91 inhibits the viral -1 programmed ribosome frame shift (-1PRF) element, and thereby inhibits the replication of SARS-CoV 2.
    SARS-CoV-2-IN-91
  • HY-163882
    CUHK242 2408055-05-8 98%
    CUHK242 is a bacterial transcription inhibitor, with a MIC of 2 μg/mL for B. subtilis reporter strain BS2019. CUHK242 has antimicrobial activity against Staphylococcus aureus. CUHK242 can inhibit RNA synthesis in cells, thereby simultaneously reducing protein synthesis.
    CUHK242
  • HY-163890
    Succinate dehydrogenase-IN-2 3023681-83-3 98%
    Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC50 of 0.52-3.42 mg/L.
    Succinate dehydrogenase-IN-2
  • HY-163906
    Anti-MRSA agent 16 3057628-14-2 98%
    Anti-MRSA agent 16 (Compound 4) is an inhibitor of methicillin-resistant Staphylococcus aureus (MRSA). Anti-MRSA agent 16 is effective in combination with oxacillin or meropenem in infected mice.
    Anti-MRSA agent 16
  • HY-163911
    SDH-IN-19 98%
    SDH-IN-19 (compound A13) is a fungicide, with an EC50 value of 0.83 μg/mL against Rhizoctonia solani. SDH-IN-19 can be used in antifungal research of crops.
    SDH-IN-19
  • HY-163912
    JZD-07 2917528-98-2 98%
    JZD-07 is a potent SARS-CoV 3CLpro inhibitor. JZD-07 can be used in the study of SARS-CoV-2 infection.
    JZD-07
  • HY-163967
    Clindamycin 2,4-diphosphate 1309048-48-3 98%
    Clindamycin 2,4-diphosphate is a related impurity of Clindamycin phosphate (HY-B1064), a prodrug of Clindamycin (HY-B1455). Clindamycin phosphate inhibits protein synthesis by targeting the bacterial ribosomal 50S subunit.
    Clindamycin 2,4-diphosphate
  • HY-163979
    Antifungal agent 109 98%
    Antifungal agent 109 (compound F) is a spirothiazolidinone compound with antifungal activity, with an inhibition zone of 10-17 mm.
    Antifungal agent 109
Cat. No. Product Name / Synonyms Application Reactivity