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Cat. No.: HY-163882

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CUHK242

CUHK242 is a bacterial transcription inhibitor, with a MIC of 2 μg/mL for B. subtilis reporter strain BS2019. CUHK242 has antimicrobial activity against Staphylococcus aureus. CUHK242 can inhibit RNA synthesis in cells, thereby simultaneously reducing protein synthesis.

For research use only. We do not sell to patients.

CAS No.: 2408055-05-8
Formula: C₂₀H₁₃Cl₃N₂O₄S
Molecular Weight:483.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CUHK242 Chemical Structure

CAS No.: 2408055-05-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	75.7 μM Compound: 54	Cytotoxicity against human A549 cells after 48 to 72 hrs by MTT assay Cytotoxicity against human A549 cells after 48 to 72 hrs by MTT assay	[PMID: 32633513]
HepG2	CC₅₀	74.4 μM Compound: 54	Cytotoxicity against human HepG2 cells after 48 to 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 to 72 hrs by MTT assay	[PMID: 32633513]

Chemical Information

CAS No. 2408055-05-8
Molecular Weight 483.75
Formula C₂₀H₁₃Cl₃N₂O₄S
SMILES

O=C(O)C1=CC=C(Cl)C=C1NCC2=CC=C(SC3=CC=C(Cl)C(Cl)=C3)C([N+]([O-])=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lam NM, et al. Development of a luciferase-based Gram-positive bacterial reporter system for the characterization of antimicrobial agents. Appl Environ Microbiol. 2024 Jul 17:e0071724. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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CUHK242

All DNA/RNA Synthesis Isoforms