TLR7 agonist 21
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections.
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- CAS No.: 3040038-00-1
- Formule: C22H33N7O
- Masse moléculaire:411.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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human TLR7 17.53 nM (EC50) |
mTLR7 41.7 nM (EC50) |
TLR8 5932 nM (EC50) |
Chemical Information
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CAS No. 3040038-00-1
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Masse moléculaire 411.54
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Formule C22H33N7O
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SMILES
NC1=NC2=C(C(NCCCC)=N1)N(C=N2)CC3=CC=C(C=C3OC)CN(CC)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR7 agonist 21 Related Classifications
HY-163670 Related Classifications
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