TLR7 agonist 21
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections.
For research use only. We do not sell to patients.
- CAS No.: 3040038-00-1
- Formula: C22H33N7O
- Molecular Weight:411.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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human TLR7 17.53 nM (EC50) |
mTLR7 41.7 nM (EC50) |
TLR8 5932 nM (EC50) |
Chemical Information
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CAS No. 3040038-00-1
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Molecular Weight 411.54
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Formula C22H33N7O
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SMILES
NC1=NC2=C(C(NCCCC)=N1)N(C=N2)CC3=CC=C(C=C3OC)CN(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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