3040038-00-1
Chemical Structure
TLR7 agonist 21
- CAS No.: 3040038-00-1
- Formula:C22H33N7O
- Molecular Weight:411.54
InChIKey: GGIFXPRNUJZSSA-UHFFFAOYSA-N
SMILES: NC1=NC2=C(C(NCCCC)=N1)N(C=N2)CC3=CC=C(C=C3OC)CN(CC)CC
Biological Activity: TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections[1].
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TLR7 agonist 21 | TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections. | |||||||||||||||||||||
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Keywords
