2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P11250
    HVF18-a3-d 98%
    HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects.
    HVF18-a3-d
  • HY-P11251
    RI-18
    RI-18 is an antimicrobial peptide. RI-18 exhibits high affinity for bacterial plasma membranes, inducing rapid membrane permeabilization and rupture. RI-18 exhibits potent antimicrobial activity against bacteria in planktonic and biofilmforms.
    RI-18
  • HY-P11299
    EBNA-1 (386–405 aa) 3082858-70-3
    EBNA-1 (386-405 aa) is a cross-reactive viral antigen peptide. EBNA-1 (386-405 aa) has a high molecular similarity to GlialCAM (370-389 aa) and it induces the production of cross-reactive antibodies that recognize both EBV antigens and glial cells in the central nervous system, thereby triggering autoimmune responses. EBNA-1 (386-405 aa) can used for Epstein-Barr virus (EBV) infection and multiple sclerosis (MS) research.
    EBNA-1 (386–405 aa)
  • HY-P11302
    DABCYL-RAGGYIFS-(E-EDANS)-NH2 98.55%
    DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity.
    DABCYL-RAGGYIFS-(E-EDANS)-NH2
  • HY-P11323
    XIPSve peptide
    XIPSve peptide is a ComRSve receptor agonist. XIPSve peptide is promising for research of streptococcal quorum-sensing systems and antibiotic.
    XIPSve peptide
  • HY-P11324
    XIPSth peptide 1254069-52-7
    XIPSth peptide is an agonist for the streptococcal competence regulator ComR. XIPSth peptide is promising for research of bacterial infection.
    XIPSth peptide
  • HY-P11330
    L-Ala-D-Glu-m-DAP-D-Ala-D-Ala
    L-Ala-D-Glu-m-DAP-D-Ala-D-Ala is a key structured peptide of peptidoglycan of gram-negative bacteria. Peptidoglycan is a network of L-Ala-D-Glu-m-DAP-D-Ala-D-Ala cross-linking the repeated units of N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc). L-Ala-D-Glu-m-DAP-D-Ala-D-Ala can be used for bacterial metabolic labeling research.
    L-Ala-D-Glu-m-DAP-D-Ala-D-Ala
  • HY-P11340
    VMAPRTLFL 202657-61-2
    VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ- adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity.
    VMAPRTLFL
  • HY-P11342
    Verlamelin A 1619244-34-6
    Verlamelin A is a macrocyclic depsipeptide with antifungal and antiviral activity. Verlamelin A shows antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also has antiviral activity toward HSV-1 (IC50 = 16.7 μM). Verlamelin A is isolated from the entomopathogenic fungus Lecanicillium sp. Verlamelin A is useful for antifungal and antiviral research.
    Verlamelin A
  • HY-P11343
    Verlamelin B 1619237-95-4
    Verlamelin B (Compound 147) is effective against plant pathogenic fungal and is a derivative of Verlamelin (HY-N14856).Verlamelin B exhibits potent plant protective activity in vivo, particularly against rice blast and barley powdery mildew. Verlamelin B causes morphological changes in fungal cells, such as swelling or expansion. Verlamelin B exhibits weaker antifungal activity in vitro against plant pathogens such as rice blast, Dipolaris zeae, and Botrytis cinerea. Verlamelin B is useful for research on antifungal activities against plant pathogens.
    Verlamelin B
  • HY-P11367
    Boc-Ala-Gly-Pro-Arg-AMC 118850-78-5
    Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei.
    Boc-Ala-Gly-Pro-Arg-AMC
  • HY-P11369
    Pilosulin-1(86-112)
    Pilosulin-1 (86-112) is a specific peptide segment of the Pilosulin 1 protein. Pilosulin 1 is the main allergen (Myr p 1) in the venom of Australian diving ants (Myrmecia pilosula), possessing potent cytotoxicity and antibacterial activity. Pilosulin-1 (86-112) is an IgE-binding component and is a secondary allergen.
    Pilosulin-1(86-112)
  • HY-P11394
    Fibronectin binding protein peptide, D3 peptide
    Fibronectin binding protein peptide, D3 peptide is a D motif from the S. aureus Fn receptor. Fibronectin binding protein peptide, D3 peptide inhibits the binding of l25I-Fn to S. dysgalactiae.
    Fibronectin binding protein peptide, D3 peptide
  • HY-P11396
    Metalnikowin I 172430-37-4 98%
    Metalnikowin I (MetI) is a proline-rich antimicrobial peptide and DnaK inhibitor. Metalnikowin I can be derived from insects.
    Metalnikowin I
  • HY-P11398
    Tachyplesin II 98%
    Tachyplesin II is a broad-spectrum cationic antimicrobial peptide. Tachyplesin II has significant inhibitory effects on Gram-positive bacteria, Gram-negative bacteria, and some fungi. Tachyplesin II binds to bacterial membrane lipopolysaccharides through its positive charge, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin II can bind to DNA grooves, inhibiting microbial replication, and also suppressing HIV-1 replication and the proliferation of liver cancer cells.
    Tachyplesin II
  • HY-P11399
    Tachyplesin-3 98%
    Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. Tachyplesin-3 has inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi and enveloped viruses. Tachyplesin-3 binds to bacterial membrane lipopolysaccharides through positive charges, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin-3 interferes with bacterial adhesion and aggregation, prevents biofilm formation, and has a synergistic effect when used in combination with Piperacillin (HY-B1923) - Tazobactam (HY-B1418) (TZP).
    Tachyplesin-3
  • HY-P11400
    Pilosulin-2(49-75)
    Pilosulin-2 (49-75) is a polypeptide composed of 27 amino acids. Pilosulin-2 (49-75) can be isolated from the venom of Myrmecia pilosula.
    Pilosulin-2(49-75)
  • HY-P11407
    HIV-1 GAG peptide A-I 334731-59-8
    HIV-1 GAG peptide A-I is a specific HIV-1 Gag peptide sequence, known to be a CD8+ T cell epitope. HIV-1 GAG peptide A-I can be used for the research of HIV vaccines..
    HIV-1 GAG peptide A-I
  • HY-P11420
    2A/2B Dengue protease substrate 410532-55-7
    2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a peptide substrate for Dengue NS2B-NS3 protease. 2A/2B Dengue protease substrate is used for Dengue NS2B-NS3 protease substrate peptide selective inhibitor development.
    2A/2B Dengue protease substrate
  • HY-P11422
    CKS9 98%
    CKS9 is an M cell-targeting peptide. CKS9 exhibits high affinity towards M cells. CKS9 facilitates the transport of chitosan nanoparticles across the M cell to enter the follicle-associated epithelium (FAE) in Peyer’s patch (PP) of the gut. CKS9 can be used for swine dysentery research.
    CKS9
Cat. No. Product Name / Synonyms Application Reactivity