HVF18-a3-d
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects.
For research use only. We do not sell to patients.
- Formula: C111H185N31O18
- Molecular Weight:2241.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
TLR4 |
Chemical Information
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Molecular Weight 2241.85
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Formula C111H185N31O18
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Sequence
d-{Gly-Val-Phe-Arg-Leu-Lys-Lys-Trp-Leu-Lys-Lys-Val-Leu-Lys-Lys-Trp-Gly-Lys}-NH2
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Sequence Shortening
d-{GVFRLKKWLKKVLKKWGK}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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