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United States

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Cat. No.: HY-P11420

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2A/2B Dengue protease substrate

2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a peptide substrate for the Dengue NS2B-NS3 protease, with a K_i value of 12 μM. 2A/2B Dengue protease substrate is used in the development of selective peptide-based inhibitors for the Dengue NS2B-NS3 protease.

For research use only. We do not sell to patients.

CAS No.: 410532-55-7
Formula: C₃₉H₆₈N₁₆O₁₁
Molecular Weight:937.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2A/2B Dengue protease substrate Chemical Structure

CAS No.: 410532-55-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 410532-55-7
Molecular Weight 937.06
Formula C₃₉H₆₈N₁₆O₁₁
Sequence

{Ac}-Arg-Thr-Ser-Lys-Lys-Arg-{pNA}
Sequence Shortening

{Ac}-RTSKKR-{pNA}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leung D, et al. Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. J Biol Chem. 2001 Dec 7;276(49):45762-71. [Content Brief]

[2]. Nitsche C, et al. Biochemistry and medicinal chemistry of the dengue virus protease. Chem Rev. 2014 Nov 26;114(22):11348-81.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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