2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial HIV Fungal DNA Alkylator/Crosslinker
  4. Tachyplesin II

Tachyplesin II is a broad-spectrum cationic antimicrobial peptide. Tachyplesin II has significant inhibitory effects on Gram-positive bacteria, Gram-negative bacteria, and some fungi. Tachyplesin II binds to bacterial membrane lipopolysaccharides through its positive charge, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin II can bind to DNA grooves, inhibiting microbial replication, and also suppressing HIV-1 replication and the proliferation of liver cancer cells.

For research use only. We do not sell to patients.

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Tachyplesin II

Tachyplesin II Chemical Structure

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Tachyplesin II Related Antibodies

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Description

Tachyplesin II is a broad-spectrum cationic antimicrobial peptide. Tachyplesin II has significant inhibitory effects on Gram-positive bacteria, Gram-negative bacteria, and some fungi. Tachyplesin II binds to bacterial membrane lipopolysaccharides through its positive charge, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin II can bind to DNA grooves, inhibiting microbial replication, and also suppressing HIV-1 replication and the proliferation of liver cancer cells[1].

Molecular Weight

2264.73

Formula

C99H150N34O20S4
Sequence

Arg-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Arg-Gly-Ile-Cys-Tyr-Arg-Lys-Cys-Arg (Disulfide bridge:Cys3-Cys16,Cys7-Cys12)
Sequence Shortening

RWCFRVCYRGICYRKCR (Disulfide bridge:Cys3-Cys16,Cys7-Cys12)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tachyplesin II Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tachyplesin IIBacterialHIVFungalDNA Alkylator/CrosslinkerHuman immunodeficiency virusAntimicrobial peptidePichia pastorisHeterologous expressionDisulfide bondC-terminal amidationAntimicrobial spectrumMinimum inhibitory concentrationSize-exclusion chromatographyYeast codon optimizationInhibitorinhibitorinhibit

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