Metalnikowin I
Metalnikowin I (MetI) is a proline-rich antimicrobial peptide and DnaK inhibitor. Metalnikowin I can be derived from insects.
For research use only. We do not sell to patients.
- CAS No.: 172430-37-4
- Formula: C80H128N26O22S
- Molecular Weight:1838.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 172430-37-4
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Molecular Weight 1838.10
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Formula C80H128N26O22S
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Synonyms
MetI
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Sequence
Val-Asp-Lys-Pro-Asp-Tyr-Arg-Pro-Arg-Pro-Arg-Pro-Pro-Asn-Met
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Sequence Shortening
VDKPDYRPRPRPPNM
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
[1]. Seefeldt AC, et al. Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 2016 Mar 18;44(5):2429-38. [Content Brief]
[2]. Welch NG, et al. (Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members. Front Chem. 2020 Dec 1;8:607769. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Metalnikowin I Related Classifications
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