2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19260
    Lasinavir 175385-62-3 98%
    Lasinavir (CGP 61755) is a selective HIV-1 protease inhibitor with an IC50 of 1 nM. Lopinavir can be used in HIV-1 infection studies.
    Lasinavir
  • HY-19289
    MC-02479 189448-23-5 98%
    MC-02479 is a novel cephalosporin. RWJ-54428 has good activity against most of the organisms tested, including methicillin-resistant staphylococci, E. faecalis, and penicillin-resistant pneumococci, and has moderate activity against E. faecium.
    MC-02479
  • HY-19293
    HMR-3787 193752-39-5 98%
    HMR-3787 is a 2-fluoroketolide and bactericide. HMR 3787 is bactericidal against 12 H. influenzae strains.
    HMR-3787
  • HY-19481
    HCV-371 463941-20-0 98%
    HCV-371 is a highly selective, potent, and low cytotoxicity HCV NSSB (EC50 = 4.8-6.1 μM) polymerase allosteric inhibitor. HCV-371 can be used for research on hepatitis C virus infection.
    HCV-371
  • HY-19506
    AR-709 663214-64-0 98%
    AR-709 is a diaminopyrimidine antibiotic. AR-709 exhibits potent antibacterial activity against Streptococcus pneumoniae (MIC = 0.03 mg/L). AR-709 can be used for research on bacterial infections.
    AR-709
  • HY-19640
    AG-85 152503-91-8 98%
    AG-85 is a major secretion protein of Mycobacterium tuberculosis, and can be identified in ancient bone.
    AG-85
  • HY-19647
    Ritipenem acoxil 87238-52-6 98%
    Ritipenem acoxil (FCE 22891; RIPM-AC) is an oral active beta-lactamase antibiotic and can be used for study of bacterial pneumonia.
    Ritipenem acoxil
  • HY-19678
    Trospectomycin 88669-04-9 98%
    Trospectomycin (U-63366F), a Spectinomycin (HY-B1828) analogue, is a broad-spectrum antibacterial agent.
    Trospectomycin
  • HY-19688
    Sitamaquine 57695-04-2 98%
    Sitamaquine (WR 6026) is an orally active Antileishmanial agent and Succinate dehydrogenase inhibitor. Sitamaquine accumulates in the acidocalcisomes of Leishmania, induces organelle alkalization, and crosses the plasma membrane of Leishmania via temperature- and energy-independent diffusion. Sitamaquine disrupts oxidative phosphorylation in Leishmania, induces mitochondrial depolarization, oxidative stress, elevated intracellular calcium, plasma membrane depolarization, and Apoptosis-like cell death. Sitamaquine can be used in the research of leishmaniasis.
    Sitamaquine
  • HY-19814
    Toripristone 91935-26-1 98%
    Toripristone (RU-40555) is a cortisol receptor inhibitor. Toripristone combined with clarithromycin can increase the antibacterial activity of Mycobacterium avium complex infection.
    Toripristone
  • HY-19869
    VRX-480773 878670-89-4 98%
    VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS.
    VRX-480773
  • HY-19932
    MK-2748 1193902-95-2 98%
    MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ < 0.115 nM), showing only slightly weaker activity against gt3a (1.212 nM), and maintaining high inhibitory activity against drug-resistant mutant strains such as gt1b R155K (IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM). MK-2748 can be used in the research of HCV infection.
    MK-2748
  • HY-23120
    1-Hydroxyguanidine sulfate 6345-29-5
    1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity.
    1-Hydroxyguanidine sulfate
  • HY-23193
    BMS-199945 1026926-30-6 98%
    BMS-199945 is a influenza virus fusion inhibitor with the IC50 values of 0.57 μM and approximately 1 μM aganist influenza A/WSN/33 virus-induced hemolysis of chicken RBC and in the trypsin protection assay, respectively.
    BMS-199945
  • HY-23317
    N-Methyl-4-(8-phenoxyoctoxy)aniline 102759-19-3 98%
    N-Methyl-4-(8-phenoxyoctoxy) aniline (Compound 3568) is an anti-schistosomal agent. N-Methyl-4-(8-phenoxyoctoxy) aniline exhibits definite anti-Schistosoma mansoni activity in mouse models, but has high acute toxicity. N-Methyl-4-(8-phenoxyoctoxy) aniline can be used in studies related to schistosomiasis.
    N-Methyl-4-(8-phenoxyoctoxy)aniline
  • HY-24366
    Quindoxin 2423-66-7 98%
    Quindoxin is an antibacterial and growth promoter, commonly used in the livestock industry. Quindoxin exhibits clear dose-dependent mutagenic activity against Salmonella typhimurium TA98 and TA100 strains. Quindoxin can cause DNA damage and has potential genotoxicity and carcinogenic risks.
    Quindoxin
  • HY-24547
    HpFabZ-IN-1 331649-59-3 98%
    HpFabZ-IN-1 (Compound 1) is an inhibitor of the key enzyme FabZ in the Helicobacter pylori fatty acid synthesis pathway, with its IC50 value being 39.8 µM. HpFabZ-IN-1 does not possess antibacterial activity.
    HpFabZ-IN-1
  • HY-29268
    β-Carboline-1-carboxylic acid 26052-96-0 98%
    β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL).
    β-Carboline-1-carboxylic acid
  • HY-32088
    Ethyl 10-bromodecanoate 55099-31-5
    Ethyl 10-bromodecanoate is an antiinflammatory and hemostatic agent. Ethyl 10-bromodecanoate is a member of the family of linolenic acid, which includes diethyl succinate and ethyl palmitate. Ethyl 10-bromodecanoate has been shown to have antibacterial properties.
    Ethyl 10-bromodecanoate
  • HY-32717
    DH03 361162-95-0 98%
    DH03 (6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinoline-3-carbonitrile) is a SARS-CoV-2 MPro ligand. DH03 can be used as a Ligand for Target Protein for PROTAC synthesis, such as PROTAC SARS-CoV-2 Degrader-1 (HY-174233).
    DH03
Cat. No. Product Name / Synonyms Application Reactivity