2. Anti-infection
  3. HCV
  4. HCV-371

HCV-371 is a highly selective, potent, and low cytotoxicity HCV NSSB (EC50 = 4.8-6.1 μM) polymerase allosteric inhibitor. HCV-371 can be used for research on hepatitis C virus infection.

For research use only. We do not sell to patients.

HCV-371

HCV-371 Chemical Structure

CAS No. : 463941-20-0

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HCV-371 Related Antibodies

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Description

HCV-371 is a highly selective, potent, and low cytotoxicity HCV NSSB (EC50 = 4.8-6.1 μM) polymerase allosteric inhibitor. HCV-371 can be used for research on hepatitis C virus infection[1].

Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 100 μM
Compound: 1
Cytotoxicity against human HuH7 cells assessed as BrdU incorporation in to cellular DNA by counter assay
Cytotoxicity against human HuH7 cells assessed as BrdU incorporation in to cellular DNA by counter assay
[PMID: 20347591]
Huh-7 EC50
13.1 μM
Compound: 1
Antiviral activity against HCV 1b BB7 infected in human HuH7 cells after 3 days by ELISA
Antiviral activity against HCV 1b BB7 infected in human HuH7 cells after 3 days by ELISA
[PMID: 20347591]
Huh-7 EC50
13.1 μM
Compound: 1, HCV-371
Antiviral activity against HCV genotype 1b infected in human Huh7 cells assessed as decrease in viral NS5A levels after 3 days by ELISA
Antiviral activity against HCV genotype 1b infected in human Huh7 cells assessed as decrease in viral NS5A levels after 3 days by ELISA
[PMID: 21550237]
Huh-7 EC50
4.8 μM
Compound: 16
Reduction of viral RNA in Huh7 cells containing HCV sub-genomic replicon after 3 days
Reduction of viral RNA in Huh7 cells containing HCV sub-genomic replicon after 3 days
[PMID: 15588095]
Huh-7 EC50
4832 nM
Compound: HCV-371
Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis
Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis
[PMID: 18936191]
Huh-7 EC50
7840 nM
Compound: HCV-371
Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis
Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis
[PMID: 18936191]
MT4 CC50
> 20 μM
Compound: 1, HCV-371
Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay
Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay
[PMID: 24144213]
Molecular Weight

312.36

Formula

C18H20N2O3
CAS No.
SMILES

O=C(O)C[C@@]1(CCC)OCCC2=C1NC3=C2C(C#N)=CC=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HCV-371 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCV-371463941-20-0HCV371HCV 371HCVHepatitis C virusNSSBhepatitis C virusInhibitorinhibitorinhibit

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