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Cat. No.: HY-19481

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HCV-371

HCV-371 is a highly selective, potent, and low cytotoxicity HCV NSSB (EC₅₀ = 4.8-6.1 μM) polymerase allosteric inhibitor. HCV-371 can be used for research on hepatitis C virus infection.

For research use only. We do not sell to patients.

CAS No.: 463941-20-0
Formula: C₁₈H₂₀N₂O₃
Molecular Weight:312.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

HCV-371 Chemical Structure

CAS No.: 463941-20-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HCV-371 is a highly selective, potent, and low cytotoxicity HCV NSSB (EC₅₀ = 4.8-6.1 μM) polymerase allosteric inhibitor. HCV-371 can be used for research on hepatitis C virus infection^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>100 μM Compound: 1	Cytotoxicity against human HuH7 cells assessed as BrdU incorporation in to cellular DNA by counter assay Cytotoxicity against human HuH7 cells assessed as BrdU incorporation in to cellular DNA by counter assay	[PMID: 20347591]
Huh-7	EC₅₀	13.1 μM Compound: 1	Antiviral activity against HCV 1b BB7 infected in human HuH7 cells after 3 days by ELISA Antiviral activity against HCV 1b BB7 infected in human HuH7 cells after 3 days by ELISA	[PMID: 20347591]
Huh-7	EC₅₀	13.1 μM Compound: 1, HCV-371	Antiviral activity against HCV genotype 1b infected in human Huh7 cells assessed as decrease in viral NS5A levels after 3 days by ELISA Antiviral activity against HCV genotype 1b infected in human Huh7 cells assessed as decrease in viral NS5A levels after 3 days by ELISA	[PMID: 21550237]
Huh-7	EC₅₀	4.8 μM Compound: 16	Reduction of viral RNA in Huh7 cells containing HCV sub-genomic replicon after 3 days Reduction of viral RNA in Huh7 cells containing HCV sub-genomic replicon after 3 days	[PMID: 15588095]
Huh-7	EC₅₀	4832 nM Compound: HCV-371	Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis	[PMID: 18936191]
Huh-7	EC₅₀	7840 nM Compound: HCV-371	Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis	[PMID: 18936191]
MT4	CC₅₀	>20 μM Compound: 1, HCV-371	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

Chemical Information

CAS No. 463941-20-0
Molecular Weight 312.36
Formula C₁₈H₂₀N₂O₃
SMILES

O=C(O)C[C@@]1(CCC)OCCC2=C1NC3=C2C(C#N)=CC=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Howe AY, et al. Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase. Antimicrob Agents Chemother. 2004 Dec;48(12):4813-21. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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