Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors

  • J Med Chem. 2004 Dec 16;47(26):6603-8. doi: 10.1021/jm0401255.
Ariamala Gopalsamy  1 ,  Kitae Lim ,  Gregory Ciszewski ,  Kaapjoo Park ,  John W Ellingboe ,  Jonathan Bloom ,  Shabana Insaf ,  Janis Upeslacis ,  Tarek S Mansour ,  Girija Krishnamurthy ,  Murthy Damarla ,  Yelena Pyatski ,  Douglas Ho ,  Anita Y M Howe ,  Mark Orlowski ,  Boris Feld ,  John O'Connell
Affiliations
  • 1. Chemical and Screening Sciences and Infectious Diseases, Wyeth Research, Pearl River, New York 10965, USA. [email protected]
PMID: 15588095 DOI: 10.1021/jm0401255
Abstract

A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.