The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase

  • Bioorg Med Chem Lett. 2011 Jun 1;21(11):3227-31. doi: 10.1016/j.bmcl.2011.04.052.
Randy W Jackson  1 ,  Matthew G LaPorte ,  Torsten Herbertz ,  Tandy L Draper ,  Janet A Gaboury ,  Susan R Rippin ,  Ravi Patel ,  Srinivas K Chunduru ,  Christopher A Benetatos ,  Dorothy C Young ,  Christopher J Burns ,  Stephen M Condon
Affiliations
  • 1. VenatoRx Pharmaceuticals Inc., 700 Pennsylvania Drive, Exton, PA 19341, USA. [email protected]
PMID: 21550237 DOI: 10.1016/j.bmcl.2011.04.052
Abstract

We describe the structure-activity relationship of the C7-position of pyrano[3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 and 14.