2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10132
    Microgrewiapine A 1420777-30-5 98%
    Microgrewiapine A is an antagonist of nAChR. Microgrewiapine A inhibits hα4β2 and hα3β4 activity with 60% and 70% inhibition, respectively. Microgrewiapine A has selective cytotoxic against HT-29 human colon cancer cells with an IC50 of 6.8 μM.
    Microgrewiapine A
  • HY-N10318
    Erigeside II 100187-70-0 98%
    Erigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells.
    Erigeside II
  • HY-N10346
    Gluconapin potassium 245550-57-6 98%
    Gluconapin (3-Butenyl glucosinolate) potassium is an orally active aliphatic glucosinolate and also a flavor modifier. Gluconapin potassium inhibits the elevation of plasma triglyceride levels in mice. Gluconapin potassium also exhibits certain antibacterial activity.
    Gluconapin potassium
  • HY-N10349
    Gluconasturtiin 499-30-9 98%
    Gluconasturtiin is an orally active glucosinolate found in the roots of Brassica juncea and Brassica hirta. Gluconasturtiin acts as a feeding activator for P. maculipennis larvae at low concentrations, while it exhibits toxicity to the larvae at high concentrations.
    Gluconasturtiin
  • HY-N10479
    Chorismic acid 617-12-9 98%
    Chorismic acid is a precursor for the biosynthesis of aromatic amino acids and vitamins, as well as a key metabolite in tRNA modification. Chorismic acid is a critical metabolite for the synthesis of cmo5U. Deficiency of Chorismic acid inhibits the formation of cmo5U and mcmo5U. Chorismic acid can be used in studies of S. typhimurium and E. coli infections.\n
    Chorismic acid
  • HY-N10607
    6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone 114021-62-4 98%
    6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone (Compound 5) has antibacterial activity, with a MIC value of 10 μg/mL for E. coli and S. epidermis. 6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone can be isolated from Piper obliquum.
    6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone
  • HY-N1063R
    Xanthoxylin (Standard) 90-24-4 98%
    Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases.
    Xanthoxylin (Standard)
  • HY-N10754
    Aschantin 13060-15-6 98%
    Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme.
    Aschantin
  • HY-N10917
    Xanthohumol I 688360-06-7 98%
    Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity.
    Xanthohumol I
  • HY-N11102
    Thymidine-5'-diphosphate-L-rhamnose 2147-59-3 98%
    Thymidine-5'-diphosphate-L-rhamnose (dTDP-L-Rhamnose) is a key activated nucleotide sugar in bacteria, with a KD value of 13 μM for Listeria monocytogenes RmlT. Thymidine-5'-diphosphate-L-rhamnose acts as a high-energy donor for L-Rhamnose (HY-N1420), and is specifically used for the synthesis of bacterial cell wall polysaccharides, capsules and virulence factors.
    Thymidine-5'-diphosphate-L-rhamnose
  • HY-N11288
    Methyl salvionolate A 1015171-69-3 98%
    Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively.
    Methyl salvionolate A
  • HY-N11407
    Bagougeramine B 104840-34-8 98%
    Bagougeramine B is an orally active nucleoside antibiotic with antimicrobial activity, which is found in Bacillus circulans. Bagougeramine B inhibits the growth of Gram-positive and Gram-negative bacteria and some fungi.
    Bagougeramine B
  • HY-N11408
    Bagougeramine A 104840-35-9 98%
    Bagougeramine A is found in the strain of Bacillus circulans TB-2125. Bagougeramine A has activities against Gram-positive bacteria and negative bacteria.
    Bagougeramine A
  • HY-N11554
    (-)-Codonopsine 26989-20-8 98%
    (-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections.
    (-)-Codonopsine
  • HY-N11597
    Daphneolone 54835-64-2 98%
    Daphneolone is a phenolic compound. Daphneolone can be isolated from the roots of Daphneodora. Some Daphneolone analogues show anti-plant pathogenic fungi activities.
    Daphneolone
  • HY-N11698
    Bakuchicin 4412-93-5 98%
    Bakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC50 of Bakuchicin against topoisomerase II is 404 μM. Bakuchicin can be used in the research of the anti-infection field.
    Bakuchicin
  • HY-N11756
    Linearmycin A 163596-98-3 98%
    Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.
    Linearmycin A
  • HY-N11761
    4,5-Dihydropiperlonguminine 23512-53-0 98%
    4,5-Dihydropiperlonguminine is a natural product that can be isolated from the seeds of Piper tuberculatum Jacq. (Piperaceae). 4,5-Dihydropiperlonguminine is a insecticide against velvetbean caterpillars.
    4,5-Dihydropiperlonguminine
  • HY-N11778
    Bequinostatin C 152175-74-1 98%
    Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and a glutathione S-transferase pi 1 (GSTP1) inhibitor (IC50=40 μg/mL for human GSTP1).
    Bequinostatin C
  • HY-N1181R
    Tamarixetin (Standard) 603-61-2
    Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways.
    Tamarixetin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity