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Cat. No.: HY-N11554

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(-)-Codonopsine

(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections.

For research use only. We do not sell to patients.

CAS No.: 26989-20-8
Formula: C₁₄H₂₁NO₄
Molecular Weight:267.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(-)-Codonopsine Chemical Structure

CAS No.: 26989-20-8

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Sample (0.1mg)

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections^[1].

In Vitro

(-)-Codonopsine (0.5-1024 μg/mL; 18 h) inhibits Staphylococcus aureus (ATCC 29213) with a MIC of 32 μg/mL, Escherichia coli (ATCC 25922) with a MIC of 64 μg/mL^[1].
(-)-Codonopsine (0.5-1024 μg/mL; 18 h) shows no activity (MIC >1024 μg/mL) against Klebsiella pneumoniae (ATCC 700603), Proteus mirabilis (ATCC 14153), Pseudomonas aeruginosa (ATCC 27853), Acinetobacter baumannii (clinical isolate), and Candida albicans (ATCC 10231)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 26989-20-8
Molecular Weight 267.32
Formula C₁₄H₂₁NO₄
SMILES

O[C@@H]1[C@H](N([C@@H]([C@H]1O)C)C)C2=CC(OC)=C(C=C2)OC
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Nezhawy AOH, et al. Design and total synthesis of (-)-codonopsinine, (-)-codonopsine and codonopsinine analogues by O-(2-oxopyrrolidin-5-yl)trichloroacetimidate as amidoalkylating agent with improved antimicrobial activity via solid lipid nanoparticle formulations. Bioorg Med Chem. 2019;27(7):1263-1273. [Content Brief]

[2]. Hideo Iida, et al. Stereochemical revision and absolute configuration of codonopsinine. Tetrahedron Letters. Volume 27, Issue 44, 1986, Pages 5393-5396.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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