2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W342467
    Dioctyldimethylammonium chloride 5538-94-3 98%
    Dioctyldimethylammonium chloride (D821), a quaternary ammonium salt, is a bactericide. Dioctyldimethylammonium chloride exerts bactericidal activity via disruption of membrane integrity, and intracellular lysate leakage. Dioctyldimethylammonium chloride also can be used as a petroleum additive, antistatic agent, softening agent, rare metal flotation agent, and corrosion inhibitor.
    Dioctyldimethylammonium chloride
  • HY-W343592
    3-Aminoisonicotinohydrazide 64189-08-8 98%
    3-Aminoisonicotinohydrazide is an anti-bacterial agent. 3-Aminoisonicotinohydrazide exhibits inhibitory activity against Mycobacterium tuberculosis. 3-Aminoisonicotinohydrazide can be used in antibacterial research.
    3-Aminoisonicotinohydrazide
  • HY-W344656
    Isobutyl heptanoate 7779-80-8 98.0%
    Isobutyl heptanoate is a valine derivative analog. Isobutyl heptanoate can be isolated from the volatile metabolites of Aspergillus clavatus NRRL1.
    Isobutyl heptanoate
  • HY-W353842
    Octyl decyldimethyl ammonium chloride 32426-11-2 98%
    Octyl decyldimethyl ammonium chloride, a quaternary ammonium salt, is an antibacterial agent. Octyl decyldimethyl ammonium chloride disrupts cell membranes, leading to cytotoxicity. Octyl decyldimethyl ammonium chloride has risk of skin irritation and increases pro-inflammatory IL-1α secretion.
    Octyl decyldimethyl ammonium chloride
  • HY-W356181
    4,8-DiMeIQx 95896-78-9 98%
    4,8-DiMeIQx is an orally active mutagen, selective dopaminergic neurotoxicant, and DNA damaging agent. 4,8-DiMeIQx can be isolated from cooked beef, sausage, pork, and chicken. 4,8-DiMeIQx induces reverse mutations in *Salmonella typhimurium* TA98 in the presence or absence of S9 mix, and forms DNA adducts in vivo in rat liver. 4,8-DiMeIQx exhibits selective neurotoxicity toward dopaminergic neurons. 4,8-DiMeIQx shows no activity against non-dopaminergic neurons. 4,8-DiMeIQx can be used in studies related to Parkinson's disease and colorectal cancer.
    4,8-DiMeIQx
  • HY-W357413
    Chinifur 70762-66-2 98.02%
    Chinifur (Quinifuryl), a Nitrofuran derivative, is a selective inhibitor of trypanothione reductase and also a radical-generating substrate for trypanothione reductase (Ki = 4.5 μM).
    Chinifur
  • HY-W382140
    4′-C-Fluoro-2′-C-methyluridine 1613589-04-0 98%
    4′-C-Fluoro-2′-C-methyluridine is a nucleotide analog, which exhibits antiviral activity against hepatitis C virus (HCV).
    4′-C-Fluoro-2′-C-methyluridine
  • HY-W391940
    (Rac)-Amorolfine hydrochloride 106614-68-0 98%
    (Rac)-Amorolfine hydrochloride is the racemic form of Amorolfine hydrochloride. Amorolfine (Ro 14-4767/002) hydrochloride (HY-B0238) is an effective antifungal agent. Amorolfine hydrochloride inhibits the biosynthesis of ergosterol and has research potential for treating onychomycosis caused by Neoscytalidium dimidiatum.
    (Rac)-Amorolfine hydrochloride
  • HY-W392548
    1-O-(4-Hydroxybenzoyl)-glycerol 93778-15-5 98%
    1-O-4-Hydroxybenzoyl-glycerol is an antimicrobial agent against Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae, and Fusarium culmorum (20 mM, maximum inhibition rate: 70%). 1-O-(4-Hydroxybenzoyl)-glycerol stimulates low skin irritation.
    1-O-(4-Hydroxybenzoyl)-glycerol
  • HY-W394006
    2'-Deoxyuridine 5'-monophosphate 964-26-1 98%
    2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.
    2'-Deoxyuridine 5'-monophosphate
  • HY-W399439
    Aurantiogliocladin 483-54-5 98%
    Aurantiogliocladin is a weak antibiotic which was active against Staphylococcus epidermidis but not S. aureus. Aurantiogliocladin could inhibit biofilm formation.
    Aurantiogliocladin
  • HY-W413619
    Cipargamin enantiomer 1193314-24-7 98%
    Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria.
    Cipargamin enantiomer
  • HY-W415273
    Caspase-3-IN-2 62252-25-9 98%
    Caspase-3-IN-2 (Compound 4d) is the inhibitor for α-Chymotrypsin. Caspase-3-IN-2 also exhibits inhibitory activity against HIV protease and caspase 3 with an inhibition rate of 57% and 51% at 100 μM.
    Caspase-3-IN-2
  • HY-W421914
    Chlorthion 500-28-7 98%
    Chlorthion is an organic phosphorothionate insecticide. Chlorthion inhibits liver microsomal hydroxylation of testosterone.
    Chlorthion
  • HY-W422288
    (Rac)-Ketoconazole 79156-75-5 98%
    (Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections.
    (Rac)-Ketoconazole
  • HY-W423010
    Cefazedone sodium 63521-15-3 98%
    Cefazedone (Refosporen) is a first-generation cephalosporin antibiotic. Cefazedone is active against both Gram-positive and Gram-negative bacteria.
    Cefazedone sodium
  • HY-W437569
    Melicopine 568-01-4 98%
    Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC50 values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields.
    Melicopine
  • HY-W439855
    10-Norparvulenone 618104-32-8 98%
    10-Norparvulenone is an antibiotic that fights against influenza viruses and has antibacterial activity against E. coli.
    10-Norparvulenone
  • HY-W441968
    L-threo-β-Hydroxyaspartic acid 7298-98-8 98%
    L-threo-β-Hydroxyaspartic acid is an amino acid antibiotic. L-threo-β-Hydroxyaspartic acid has the activity of inhibiting Bacillus subtilis, Xanthomonas oryzae, Mycobacterium phlei and Botrytis cinerea.
    L-threo-β-Hydroxyaspartic acid
  • HY-W451820
    AN-12-H5 intermediate-3 851314-03-9
    AN-12-H5 intermediate-3 is an intermediate of the viral inhibitor AN-12-H5 (HY-120900) and can be used to synthesize Antibody-Drug Conjugates (ADCs).
    AN-12-H5 intermediate-3
Cat. No. Product Name / Synonyms Application Reactivity