Melicopine
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC50 values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields.
For research use only. We do not sell to patients.
- CAS No.: 568-01-4
- Formula: C17H15NO5
- Molecular Weight:313.30
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-141617
1-Palmitoyl-2-hydroxy-sn-glycero-3-PEOccurring Lysophospholipid -
HY-121265
Bendiocarb -
HY-N7071A
Maduramicin ammoniumAntibiotic -
HY-103056
DDD85646NMT Inhibitor -
HY-107483
CambendazoleAnthelmintic Compound -
HY-N8513
Brevicompanine BAntiplasmodial Agent -
HY-107483R
Cambendazole (Standard)Anthelmintic Compound -
HY-N9194
5-Methoxycanthin-6-oneLeishmanicidal Agent -
HY-N2384A
Febrifugine dihydrochlorideAntimalarial Agent -
HY-121265R
Bendiocarb (Standard) -
HY-N7071AR
Maduramicin ammonium (Standard)Anticoccidial Agent -
HY-114927
(±)-DunnioneAntifungal Compound
All Parasite Isoforms
More
Biological Activity
Description
Chemical Information
-
CAS No. 568-01-4
-
Molecular Weight 313.30
-
Formula C17H15NO5
-
SMILES
O=C1C2=C(N(C)C3=C4OCOC4=C(C(OC)=C13)OC)C=CC=C2
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melicopine Related Classifications
HY-W437569 Related Classifications
Powered by Bioz