2. Anti-infection
  3. Parasite
  4. Cipargamin enantiomer

Cipargamin enantiomer  (Synonyms: NITD609 enantiomer; KAE609 enantiomer)

Cat. No.: HY-W413619
Handling Instructions Technical Support

Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria.

For research use only. We do not sell to patients.

Cipargamin enantiomer

Cipargamin enantiomer Chemical Structure

CAS No. : 1193314-24-7

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Other Forms of Cipargamin enantiomer:

Cipargamin enantiomer Related Antibodies

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Description

Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria[1].

In Vitro

Cipargamin enantiomer (Compound 19b) inhibits the growth of Plasmodium falciparum NF54 strain with an IC50 of 77 nM[1].
Cipargamin enantiomer has low metabolic clearance in human and mouse liver microsomes[1].
Cipargamin enantiomer (≤10.00 μM) does not inhibit CYP2C9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cipargamin enantiomer Related Antibodies
Parmacokinetics
Species Dose Route CL
Mice[1] 5 mg/kg i.v. 2.58 mL/min/kg
Molecular Weight

390.24

Formula

C19H14Cl2FN3O
CAS No.
SMILES

FC1=C(Cl)C=C(NC2=C3C[C@@H](C)N[C@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cipargamin enantiomer Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cipargamin enantiomer1193314-24-7NITD609 enantiomer KAE609 enantiomerParasitePlasmodium falciparumCYP 2C9miceNF54malariahuman liver microsomesK1mouse liver microsomesInhibitorinhibitorinhibit

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