Cipargamin enantiomer
Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria.
For research use only. We do not sell to patients.
- CAS No.: 1193314-24-7
- Formula: C19H14Cl2FN3O
- Molecular Weight:390.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Cipargamin enantiomer (Compound 19b) inhibits the growth of Plasmodium falciparum NF54 strain with an IC50 of 77 nM[1].
Cipargamin enantiomer has low metabolic clearance in human and mouse liver microsomes[1].
Cipargamin enantiomer (≤10.00 μM) does not inhibit CYP2C9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | CL |
|---|---|---|---|
| Mice[1] | 5 mg/kg | i.v. | 2.58 mL/min/kg |
Chemical Information
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CAS No. 1193314-24-7
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Molecular Weight 390.24
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Formula C19H14Cl2FN3O
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SMILES
FC1=C(Cl)C=C(NC2=C3C[C@@H](C)N[C@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1
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Synonyms
NITD609 enantiomer; KAE609 enantiomer
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cipargamin enantiomer Related Classifications
HY-W413619 Related Classifications
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