1193314-24-7
Chemical Structure
Cipargamin enantiomer
Synonym(s): NITD609 enantiomer; KAE609 enantiomer
- CAS. Nr.: 1193314-24-7
- Formula:C19H14Cl2FN3O
- Molecular Weight:390.24
IUPAC Name: (1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methanamine
InChIKey: CKLPLPZSUQEDRT-YLVJLNSGSA-N
SMILES: FC1=C(Cl)C=C(NC2=C3C[C@@H](C)N[C@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1
Biological Activity: Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria[1].
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Cipargamin enantiomer | Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC50 of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria. | |||||||||||||||||||||
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Keywords
