2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-180548
    MRC37 98.90%
    MRC37 is a potent and selective small-molecule ligand of TRIM21 that binds the PRYSPRY domain of TRIM21. MRC37 inhibits the natural antiviral function of TRIM21 by preventing antibody neutralisation of adenovirus 5 (Adv5). MRC37 is also capable of inhibiting Trim-Away, a targeted protein degradation technology where TRIM21 is recruited to specific proteins via electroporated antibodies.
    MRC37
  • HY-181006
    TSLP modulator-1 99.61%
    TSLP modulator-1 (Compound 14O) is a potent TSLP signaling modulator. TSLP modulator-1 exhibits potent inhibition of CCL17 and IL-1β mRNA expression. TSLP modulator-1 attenuates the protein levels of IL-6, IL-4 and IL-13. TSLP modulator-1 significantly attenuates calcium influx. TSLP modulator-1 exerts anti-inflammatory effects. TSLP modulator-1 effectively alleviates pruritus and atopic dermatitis-like symptoms.
    TSLP modulator-1
  • HY-181126
    G194-0712 1029737-28-7 99.82%
    G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds.
    G194-0712
  • HY-181133
    Budesonide oleate (C18:1) 102668-87-1 99.26%
    Budesonide oleate (C18:1) (Budesonide 21-oleate) is a prodrug of Budesonide (HY-13580), and can be used as the active ingredient of anti-inflammatory lipid nanoparticles for targeted delivery of anti-inflammatory agents.
    Budesonide oleate (C18:1)
  • HY-181654
    Snail IN-1 3083216-69-4 98.27%
    Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail-CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis.
    Snail IN-1
  • HY-183326
    Isosorbide di-(methyl fumarate) 2013542-44-2 99.87%
    Isosorbide di-(methyl fumarate) (IDMF), topical DMF (HY-17363) derivative, is an NRF2/ARE pathway activator. Isosorbide di-(methyl fumarate) downregulates ANCR targets, modulates epithelial differentiation, represses proinflammatory cytokine genes, IL-17A- and TNF-induced keratinocyte genes, psoriatic skin lesion-specific genes, and immune response genes. Isosorbide di-(methyl fumarate) stimulates oxidative stress response gene transcription, reduces erythema and scaling in Imiquimod (HY-B0180)-induced psoriasiform lesions. Isosorbide di-(methyl fumarate) exhibits no genotoxicity or radiation sensitivity in skin fibroblasts, is nonirritating and nonsensitizing in rodent models. Isosorbide di-(methyl fumarate) can be used for the research of psoriasis vulgaris.
    Isosorbide di-(methyl fumarate)
  • HY-186080
    Melatonin-OH 67199-08-0 98.72%
    Melatonin-OH is an oxidative Melatonin (HY-B0075) metabolite with free radical-scavenging activity. Melatonin-OH forms via Melatonin’s reaction with hydroxyl radicals (·OH). Melatonin-OH forms via Melatonin’s reaction with peroxynitrous acid or its activated form ONOOH.
    Melatonin-OH
  • HY-186112
    PSFL2915 88134-39-8 98.72%
    PSFL2915 is a selective, orally active P2X receptor inhibitor with oral effectiveness, with an IC50 of 0.319 μM for human P2X3, 0.261 μM for rat P2X2/3, and 13.3 μM for human P2X2. PSFL2915 exhibits ~42-fold selectivity over human P2X2. PSFL2915 can be used for the research of chronic cough.
    PSFL2915
  • HY-186178
    CD38-IN-6 2766686-04-6 99.96%
    CD38-IN-6 is an orally active CD38 inhibitor. CD38-IN-6 regulates NAD+ metabolite levels in the liver of aged obese mice by increasing NAD+ and NMN levels, and decreasing NAM and ADPR levels. CD38-IN-6 alleviates inflammatory responses in mice. CD38-IN-6 can be used for research related to obesity and inflammation.
    CD38-IN-6
  • HY-30151S
    Methoxsalen-d3 80386-99-8 99.93%
    Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
    Methoxsalen-d3
  • HY-404632
    TRPM3-IN-1 2776193-88-3
    TRPM3-IN-1 (compound 124) is an inhibitor of TRPM3 with an IC50 value <1 µM. TRPM3-IN-1 can be used in the research of pain and inflammatory[1]
    TRPM3-IN-1
  • HY-76025S
    1,4-Dibromobenzene-d4 4165-56-4 99.94%
    1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans.
    1,4-Dibromobenzene-d4
  • HY-77839S
    Cortodoxone-d5 1258063-56-7 ≥99.0%
    Cortodoxone-d5 is the deuterium labeled Cortodoxone.
    Cortodoxone-d5
  • HY-A0015A
    (Rac)-Bepotastine besilate 1415692-17-9 99.52%
    (Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research.
    (Rac)-Bepotastine besilate
  • HY-A0143S
    Dihomo-γ-linolenic acid-d6 81540-86-5 99.0%
    Dihomo-γ-linolenic acid-d6 (DGLA-d6) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.
    Dihomo-γ-linolenic acid-d6
  • HY-B0147A
    Pefloxacin mesylate 70458-95-6 99.73%
    Pefloxacin (Pefloxacinium) mesylate is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin mesylate inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin mesylate exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin mesylate has anti-Plasmodium yoelii infection activity. Pefloxacin mesylate increase UVA-induced edema and immunesuppression. Pefloxacin mesylate can be used for infection studies.
    Pefloxacin mesylate
  • HY-B0198A
    Cefaclor monohydrate 70356-03-5 ≥98.0%
    Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections.
    Cefaclor monohydrate
  • HY-B0214S
    Prednisone-d8 98.00%
    Prednisone-d8 is the deuterium labeled Prednisone. Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
    Prednisone-d8
  • HY-B0328R
    Triamcinolone (Standard) 124-94-7 98.02%
    Triamcinolone (Standard) is the analytical standard of Triamcinolone. This product is intended for research and analytical applications.
    Triamcinolone (Standard)
  • HY-B0352R
    Mirtazapine (Standard) 85650-52-8 99.95%
    Mirtazapine (Standard) is the analytical standard of Mirtazapine. This product is intended for research and analytical applications. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively.
    Mirtazapine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity