Cat. No.: HY-B0198A

Cefaclor monohydrate

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections.

For research use only. We do not sell to patients.

Purity: 99.11%
CAS No.: 70356-03-5
Formula: C₁₅H₁₆ClN₃O₅S
Molecular Weight:385.82

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cefaclor monohydrate Chemical Structure

CAS No.: 70356-03-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

β-lactam

5-HT Receptor

hOAT1

hPepT1-human peptide transporter 1

hPepT2-human peptide transporter 2

CD63

BDNF

All Antibiotic Isoforms :

All 5-HT Receptor Isoforms :

In Vitro

Cefaclor (0-500 μg/mL, 12-24 h) shows obvious antibacterial activity against 556 Gram-positive and Gram-negative isolates. The MIC values of most strains are lower than 3.1 μg/mL, and the MIC value of Staph. aureus is 1 μg/mL in vitro^[4].
Cefaclor (60/500 μM, 30 min) is mainly transported by hPepT2 and hPepT1 in the MDCK stably transduced cell line overexpressing hOAT1, hPepT1 and hPepT2^[2].
Cefaclor (0.16 mg/mL, 30 min) can induce allergic reactions by directly activating basophils and mast cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cefaclor (200 mg/kg/day, p.o. once a day for 5 days) can cause intestinal flora imbalance in mice, as well as anxiety and depression-like behaviors in mice. These symptoms can be alleviated by Fluoxetine (HY-B0102) or vagotomy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (male, 5 weeks old)^[1]
Dosage:

200 mg/kg/day, once a day for 5 days.
Administration:

p.o.
Result:

Significantly decreased serotonin levels in the hippocampus and BDNF in mice.
Cefaclor-induced gut dysbiosis caused anxiety and depression through the microbiota-gut-blood–brain and the microbiota-gut-vagus nerve-brain pathway.

Chemical Information

CAS No. 70356-03-5
Appearance Solid
Molecular Weight 385.82
Formula C₁₅H₁₆ClN₃O₅S
Color Off-white to light yellow
SMILES

O=C(C(N12)=C(Cl)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O.[H]O[H]
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Nat Commun

Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO. [Abstract]

2023 Mar 22;14(1):1594. PMID: 36949052
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996

Solvent & Solubility

In Vitro:

DMSO : 5.83 mg/mL (15.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5919 mL

12.9594 mL

25.9188 mL

5 mM

0.5184 mL

2.5919 mL

5.1838 mL

10 mM

0.2592 mL

1.2959 mL

2.5919 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. 引用1 ：Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19;13(1):15529. [Content Brief]

[2]. Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. [Content Brief]

[3]. Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov;55(6):1473-83. [Content Brief]

[4]. Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5919 mL	12.9594 mL	25.9188 mL	64.7971 mL
	5 mM	0.5184 mL	2.5919 mL	5.1838 mL	12.9594 mL
	10 mM	0.2592 mL	1.2959 mL	2.5919 mL	6.4797 mL
	15 mM	0.1728 mL	0.8640 mL	1.7279 mL	4.3198 mL

Keywords

Cefaclor monohydrate

2 Cited Publications

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Cefaclor monohydrate

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Publications Citing Use of MedChemExpress (MCE) Cefaclor monohydrate

All Antibiotic Isoforms

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cefaclor monohydrate Related Classifications

Cat. No.: HY-B0198A