2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. MRC37

MRC37 is a potent and selective small-molecule ligand of TRIM21 that binds the PRYSPRY domain of TRIM21. MRC37 inhibits the natural antiviral function of TRIM21 by preventing antibody neutralisation of adenovirus 5 (Adv5). MRC37 is also capable of inhibiting Trim-Away, a targeted protein degradation technology where TRIM21 is recruited to specific proteins via electroporated antibodies.

For research use only. We do not sell to patients.

MRC37

MRC37 Chemical Structure

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5 mg In-stock
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MRC37 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

MRC37 is a potent and selective small-molecule ligand of TRIM21 that binds the PRYSPRY domain of TRIM21. MRC37 inhibits the natural antiviral function of TRIM21 by preventing antibody neutralisation of adenovirus 5 (Adv5). MRC37 is also capable of inhibiting Trim-Away, a targeted protein degradation technology where TRIM21 is recruited to specific proteins via electroporated antibodies[1].

Molecular Weight

535.68

Formula

C30H41N5O4
Appearance

Solid

Color

White to off-white

SMILES

O=C(C[C@H](N)C1=C(OC)C=CC=C1)N(C2)[C@H](C(N[C@@H](CC3=CC=NC=C3)C(NC)=O)=O)C[C@H]2C4CCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (466.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8668 mL 9.3339 mL 18.6679 mL
5 mM 0.3734 mL 1.8668 mL 3.7336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.90%

SDS (252 KB)

COA (258 KB) HNMR (164 KB) LCMS (79 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8668 mL 9.3339 mL 18.6679 mL 46.6697 mL
5 mM 0.3734 mL 1.8668 mL 3.7336 mL 9.3339 mL
10 mM 0.1867 mL 0.9334 mL 1.8668 mL 4.6670 mL
15 mM 0.1245 mL 0.6223 mL 1.2445 mL 3.1113 mL
20 mM 0.0933 mL 0.4667 mL 0.9334 mL 2.3335 mL
25 mM 0.0747 mL 0.3734 mL 0.7467 mL 1.8668 mL
30 mM 0.0622 mL 0.3111 mL 0.6223 mL 1.5557 mL
40 mM 0.0467 mL 0.2333 mL 0.4667 mL 1.1667 mL
50 mM 0.0373 mL 0.1867 mL 0.3734 mL 0.9334 mL
60 mM 0.0311 mL 0.1556 mL 0.3111 mL 0.7778 mL
80 mM 0.0233 mL 0.1167 mL 0.2333 mL 0.5834 mL
100 mM 0.0187 mL 0.0933 mL 0.1867 mL 0.4667 mL
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MRC37 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRC37MRC 37MRC-37E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasesmall-molecule ligandTrim-Awaytargeted protein degradation technologyInhibitorinhibitorinhibit

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