2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-123876
    AS2677131 2171502-44-4 98%
    AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis.
    AS2677131
  • HY-123878
    DS79182026 2113642-80-9 98%
    DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model.
    DS79182026
  • HY-123924
    CSLP37 2244984-64-1 98%
    CSLP37 is a selective RIPK2 inhibitor with an IC50 of 16.3 nM. CSLP37 shows no inhibitory activity against RIPK1 and RIPK3. CSLP37 displays potent suppression of cellular NOD1 and NOD2 responses.
    CSLP37
  • HY-123925
    CSLP43 2244988-80-3 98%
    CSLP43 is a selective RIPK2 and XIAP inhibitor with an IC50 of 19.9 nM against human RIPK2. CSLP43 binds to the ATP-binding pocket of RIPK2 and disrupts the interaction between RIPK2 and the BIR2 domain of XIAP or cIAP1. CSLP43 inhibits RIPK2 ubiquitination, NOD1-dependent inflammatory signaling pathways, NOD2-dependent inflammatory signaling pathways, as well as NF-κB activation associated with NOD agonists. CSLP43 is selective for the NOD1/NOD2 signaling pathway and does not inhibit the kinase activity of RIPK1 or RIPK3. CSLP43 is applicable to research related to Crohn's disease, Blau syndrome, early-onset sarcoidosis and early-onset inflammatory bowel disease.
    CSLP43
  • HY-123956
    HG-12-6 2222354-57-4 98%
    HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.
    HG-12-6
  • HY-123958
    SB772077B 785774-34-7 98%
    SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research.
    SB772077B
  • HY-123970
    ISO-92 899433-49-9 98%
    ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research.
    ISO-92
  • HY-124040
    BI-1950 1159724-42-1 98%
    BI-1950 is a lymphocyte function-associated antigen 1 (LFA-1) inhibitor. BI-1950 regulates immune system function through interaction with LFA-1. BI-1950 can be used in the research of inflammatory diseases.
    BI-1950
  • HY-124065
    ARRY-502 1202891-16-4 98%
    ARRY-502 is an orally active, potent and selective CRTh2 antagonist. ARRY-502 blocks PGD2-mediated Th2 inflammation (e.g., eosinophil activation, airway hyperresponsiveness). ARRY-502 is promising for research of Th2-related asthma.
    ARRY-502
  • HY-124099
    SCH 40120 110545-79-4 98%
    SCH 40120 is a potent leukotriene inhibitor with antiinflammatory effects. SCH 40120 suppresses T cell proliferative responses, antigen-specific and poly-clonally-induced in vitro antibody responses. SCH 40120 suppresses an edematous response and inhibits the recruitment of circulating neutrophils into sites of inflammation. SCH 40120 is proming for rasearch of anti-psoriatic agents.
    SCH 40120
  • HY-124148
    Fenimide 60-45-7 98%
    Fenimide is an antipsychotic agent. Fenimide shows sedative, anticonvulsant and anesthetic activity. Fenimide has also prevented formation of stress-induced gastric lesions in the rat.
    Fenimide
  • HY-124153
    GNE-431 1433820-83-7 98%
    GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases.
    GNE-431
  • HY-124183
    SX-576 1240494-14-7 98%
    SX-576 is a CXCR1 and CXCR2 antagonist with IC50 values of 31 nM and 21 nM, respectively. SX-576 inhibits neutrophil infiltration in a rat model of pulmonary inflammation. SX-576 can be used in studies related to pulmonary inflammation.
    SX-576
  • HY-124240
    SRTCX1003 1203480-86-7 98%
    SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses.
    SRTCX1003
  • HY-124241
    N-Cyclopropyl bimatoprost 1138395-12-6 98%
    N-Cyclopropyl bimatoprost (Formula II), a prostaglandin analog, can be used in the study of epithelial-related conditions.
    N-Cyclopropyl bimatoprost
  • HY-124270
    Sibenadet hydrochloride 154189-24-9 98%
    Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.
    Sibenadet hydrochloride
  • HY-124283
    LEI-101 free base 1228660-00-1 98%
    LEI-101 free base is a selective and orally bioavailable CB2 receptor agonist with the potential to inhibit diseases associated with inflammation and/or oxidative stress. LEI-101 free base has a binding potency to CB2 receptors that is approximately 100 times higher than that to CB1 receptors. Its pEC50 value on CB2 receptors is 8, while its pKi value on hERG is less than 4. LEI-101 may have an inhibitory effect on conditions such as kidney disease.
    LEI-101 free base
  • HY-124286
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone 1675245-06-3 98%
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone (C14-9Z-HSL) is an autoinducer in C. rodentium, that serves as signal molecule, coordinates the gene expression and behaviors through diffusion into cells of different bacterial species.
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone
  • HY-124345
    2-Trifluoromethyl-2'-methoxychalcone 1309371-03-6 98%
    2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative. 2-Trifluoromethyl-2'-methoxychalcone is a potent Nrf2 activator. 2-Trifluoromethyl-2'-methoxychalcone can be used for oxidative stress and inflammation related diseases research.
    2-Trifluoromethyl-2'-methoxychalcone
  • HY-124356
    Alcaftadine carboxylic acid 147083-93-0 98%
    Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01%.
    Alcaftadine carboxylic acid
Cat. No. Product Name / Synonyms Application Reactivity