2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128934
    Antitumor agent-2 1351163-57-9 98%
    Antitumor agent-2 is sourced from patent CN102250203, compound 6a-r, has antitumor action and anti-inflammatory action.
    Antitumor agent-2
  • HY-129214
    (2S,3R)-DEPMPO-Biotin 936224-52-1 98%
    (2S,3R)-DEPMPO-Biotin is a spin trapping agent consists of DEPMPO (HY-120976) and Biotin (HY-B0511). (2S,3R)-DEPMPO-Biotin captures macromolecule free radicals in lesions.
    (2S,3R)-DEPMPO-Biotin
  • HY-129289
    NSC 13987 81-94-7 98%
    NSC 13987 is a Nef site I inhibitor. NSC 13987 binds to Nef site I and disrupts the Nef-calnexin interaction. NSC 13987 restores cholesterol efflux inhibited by Nef. NSC 13987 is applicable to the research of HIV-associated atherosclerosis.
    NSC 13987
  • HY-129311
    Tr-PEG6-OH 127999-16-0
    Tr-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Tr-PEG6-OH
  • HY-129424
    Mezolidon 82697-73-2 98%
    Mezolidon (KM-1146) is an anti-ulcer agent with weak gastric acid secretion inhibitory activity. Mezolidon prevents the formation of gastric mucosal ulcers in stressed rats, increases and maintains their gastric mucosal blood flow, and inhibits the decrease in their transmucosal potential difference. Mezolidon can be used in the research of gastric ulcers.
    Mezolidon
  • HY-129442
    MNA 279 185915-32-6 98%
    MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE)-like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model.
    MNA 279
  • HY-129466
    PCTR2 1810710-63-4 98%
    PCTR2 is a protectin sulfidoconjugate, which is a pro-resolving mediator that exhibits activity towards inflammation and tissue regeneration.
    PCTR2
  • HY-12946A
    BI 653048 phosphate 1198784-97-2 98%
    BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 phosphate is extracted from patent WO2005028501A1 (Compound 103), is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus.
    BI 653048 phosphate
  • HY-129471
    Arbaprostil 55028-70-1 98%
    Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect.
    Arbaprostil
  • HY-129546
    Eprozinol hydrochloride 27588-43-8 98%
    Eprozinol hydrochloride is a compound with antibronchoconstrictor activity. Eprozinol hydrochloride can be used in the study of bronchospasm.
    Eprozinol hydrochloride
  • HY-129577
    Aplysin 6790-63-2 98%
    Aplysin is a brominated sesquiterpene with an isoprene backbone that exhibits hepatoprotective, immunomodulatory, and antitumor activities. Aplysin effectively prevents spontaneous pancreatic necrosis and inflammatory responses in NOD mice.
    Aplysin
  • HY-129664
    L 683519 132172-14-6 98%
    L 683519, one of the impurities of tacrolimus, is an immunosuppressant. L 683519 can inhibit the activity of FK-506 binding protein.
    L 683519
  • HY-129670
    KMUP-1 81996-46-5
    KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC). KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K+ channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study.
    KMUP-1
  • HY-129684
    IAXO-101 iodide 1202388-64-4 98%
    IAXO-101 iodide is a TLR4/CD14 blocker. IAXO-101 iodide can inhibit the innate immune pathway of CD14. IAXO-101 iodide is capable of improving the recording performance of intracortical microelectrodes in mice. IAXO-101 iodide can also partially alleviate fetal growth restriction, placental vascular damage, and reduce the level of the inflammatory factor TNF-α in pregnant mice infected with malaria. IAXO-101 iodide can be used in the research of gestational malaria and inflammatory diseases.
    IAXO-101 iodide
  • HY-129690
    UK-356202 223671-94-1 98%
    UK-356202 is a urokinase-type plasminogen activator (uPA) with a Ki value of 0.037 μM. UK-356202 can be used in research related to the topical treatment of chronic ulcerous wounds.
    UK-356202
  • HY-129716
    L-693989 138661-20-8 98%
    L-693989 is an orally active water-soluble lipopeptide with anticandidal and antipneumocystis activity. L-693989 is effective in preventing the development of both P. carinii cysts. L-693989 is promising for research of P. carinii pneumonia.
    L-693989
  • HY-129724
    α-MSH (11-13) 67727-97-3 98%
    α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections.
    α-MSH (11-13)
  • HY-129728
    Lienomycin 12710-02-0 98%
    Lienomycin, a polyene antibiotic produced by Actinomyces distatochromogenes var. lienomycini, exhibits antifungal, antibacterial and antitumor activity.
    Lienomycin
  • HY-129749
    IDO-IN-13 2291164-02-6 98%
    IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM, extracted from patent WO2019040102A1, example 43.
    IDO-IN-13
  • HY-129761
    AR 17048 65792-35-0 98%
    AR 17048 is a potent antirheumatic agent.
    AR 17048
Cat. No. Product Name / Synonyms Application Reactivity