Arbaprostil
Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect.
For research use only. We do not sell to patients.
- CAS No.: 55028-70-1
- Formula: C21H34O5
- Molecular Weight:366.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Arbaprostil (1-100 μg/kg, p.o., single dose) pH-dependently inhibits gastric secretion, promotes the gastric ucler healing (3-10 μg/kg, p.o., twice daily for 4 weeks) in Donryu rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rat[1]
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Dosage:1-100 μg/kg
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Administration:i.v., single dose
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Result:Increased secrection of HCO3+.
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Animal Model:Donryu rats[2]
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Dosage:1-100 μg/kg
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Administration:1-100 μg/kg, p.o. and i.d. (intraduodenally), single dose; 3-10 μg/kg, p.o., twice daily for 4 weeks
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Result:Inhibited the gastric secretion when intraduodenally administrated.
Increased the gastric secretion when orally administrated.
Accelerated the healing rate of gastric ucler.
Chemical Information
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CAS No. 55028-70-1
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Molecular Weight 366.49
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Formula C21H34O5
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SMILES
CCCCC[C@@](O)(/C=C/[C@H]1[C@@H](CC([C@@H]1C/C=C\CCCC(O)=O)=O)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Li JY, Nagata T, Yoshida M, Yagi N, Katoh K, Haramoto T, Itoh K, Iwasaki A, Matsuo Y. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenterol Jpn. 1989 Feb;24(1):8-11. [Content Brief]
[2]. Okabe S, et al., Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. Jpn J Pharmacol. 1986 Feb;40(2):329-37. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Arbaprostil Related Classifications
HY-129471 Related Classifications
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