55028-70-1
55028-70-1
Chemical Structure
Arbaprostil
- CAS No.: 55028-70-1
- Formula:C21H34O5
- Molecular Weight:366.49
IUPAC Name: (Z)-7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-3-methyloct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid
InChIKey: XSGQFHNPNWBVPT-VFXMVCAWSA-N
SMILES: CCCCC[C@@](O)(/C=C/[C@H]1[C@@H](CC([C@@H]1C/C=C\CCCC(O)=O)=O)O)C
Biological Activity: Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect[1][2].
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Arbaprostil | Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect. | |||||||||||||||||||||
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References
- [1]. Li JY, Nagata T, Yoshida M, Yagi N, Katoh K, Haramoto T, Itoh K, Iwasaki A, Matsuo Y. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenterol Jpn. 1989 Feb;24(1):8-11. [Content Brief]
- [2]. Okabe S, et al., Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. Jpn J Pharmacol. 1986 Feb;40(2):329-37. [Content Brief]
Keywords
